Results 131 to 140 of about 1,684,114 (372)
SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity
Autoimmunity, 2018 Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs.
Christopher H. Mauney, Thomas Hollis
doaj +1 more source
Pathways of Oxidation in Cell-free Potato Fractions. II. Properties of the Soluble Pyridine Nucleotide Oxidase System. [PDF]
, 1958 David P. Hackett
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Structural Fluctuations of Microtubule Binding Site of KIF1A in Different Nucleotide States [PDF]
arXiv, 2008 How molecular motors like Kinesin regulates the affinity to the rail protein in the process of ATP hydrolysis remains to be uncovered. To understand the regulation mechanism, we investigate the structural fluctuation of KIF1A in different nucleotide states that are realized in the ATP hydrolysis process by molecular dynamics simulations of Go-like ...
arxiv
FEBS Open Bio, EarlyView.We provide a step‐by‐step guide for producing E140 antigen fragments from Plasmodium berghei (Pb1) and Plasmodium vivax (Pv1). Pb1/Pv1 are expressed in E. coli, solubilized by freeze–thawing, refolded by slow dilution, purified by affinity chromatography (IMAC), then concentrated and subjected to quality control.
Rodolfo Ferreira Marques +5 more
wiley +1 more source
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
Nature Communications, 2018 Oncogenic KRAS is the key driver of pancreatic ductal adenocarcinoma (PDAC). We previously described a role for KRAS in PDAC tumor maintenance through rewiring of cellular metabolism to support proliferation.
Naiara Santana-Codina +10 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Mathematical Biosciences and Engineering, 2019 In the classical chemostat, the output of the system has no effect on its input. This contrasts with many ecological systems, where the output at the end of a growing season affects nutrient inputs for subsequent seasons.
Irakli Loladze
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Correlations between promoter activity and its nucleotide positions in spacing region [PDF]
arXiv, 2015 Transcription is one of the essential processes for cells to read genetic information encoded in genes, which is initiated by the binding of RNA polymerase to related promoter. Experiments have found that the nucleotide sequence of promoter has great influence on gene expression strength, or promoter activity.
arxiv
Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding
FEBS Open Bio, EarlyView.The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla +4 more
wiley +1 more source
Structure of Dihydrodiphosphopyridine Nucleotide [PDF]
, 1959 Sidney Shifrin, Nathan O. Kaplan
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