Results 131 to 140 of about 2,047,681 (342)

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

The Acid-soluble Nucleotides of Barley and Oat Plants. [PDF]

, 1957
Rolf Bergkvist, Gunnel Westöö, Lars Svennerholm, Arne Magnéli, Arne Magnéli, Herbert Pestmalis, Stig Åsbrink   +6 more
openalex   +1 more source

A key variant in the cis-regulatory element of flowering gene Ghd8 associated with cold tolerance in rice. [PDF]

, 2019
Variations in the gene promoter play critical roles in the evolution of important adaptive traits in crops, but direct links of the regulatory mutation to the adaptive change are not well understood.
Fan, Kai, Gong, Rong, Wang, Peng, Xiong, Yin, Yang, Ying, Yu, Sibin   +5 more
core  

NUCLEOTIDE PYROPHOSPHATASE AND TRIPHOSPHOPYRIDINE NUCLEOTIDE STRUCTURE [PDF]

Journal of Biological Chemistry, 1948
openaire   +2 more sources

The nucleotides that bind [PDF]

Nature Structural & Molecular Biology, 2021
openaire   +2 more sources

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

To the Question of Rhododendron L. Genus Phylogeny Based on ITS1-ITS2 Spacers Sequence Studies [PDF]

Сибирский лесной журнал, 2014
The first and second internal transcribed spacer (ITS1 and ITS2) regions of the ribosomal DNA and 5.8S rRNA gene from Rhododendron L. were analysed.
T. V. Baranova, R. N. Kalendar
doaj  

味噌醤油酵母Zygosaccharomyces酵母の接合遺伝子座(mating-type-like (MTL) loci)の多様性 [PDF]

, 2018
Variations of chromosomal structures and nucleotide sequences around mating-type-like (MTL) loci among Zygosaccharomyces species have been reported.
Ogata, Tomoo, オガタ, トモオ, 尾形, 智夫   +2 more
core  

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source