Results 181 to 190 of about 1,387,306 (292)

Nucleotide [PDF]

, 2020
openaire   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

De novo nucleotide biosynthesis and its dynamic regulation are crucial for systemic infection by extraintestinal Escherichia coli. [PDF]

PLoS Pathog
Zhang C, Yang Y, Wang S, Liu Y, Zhao X, Yin F, Hu Y, Xue Y, Bu Z, Li S, Tan C, Zhou R, Huang Q.   +12 more
europepmc   +1 more source

The importance of dopamine levels and single-nucleotide polymorphism within COMT , DRD1 and DRD2 genes in obstructive sleep apnoea [PDF]

Joanna Smardz, Helena Martynowicz, Marta Dratwa-Kuźmin, Anna Wojakowska, Paweł Gać, Katarzyna Bogunia‐Kubik, Mieszko Więckiewicz   +6 more
openalex   +1 more source

New nucleotide sequence data on the EMBL File Server [PDF]

, 1992
P Purdue, M Lumb, M Fox, G Griffo, C Hamon-Benais, S Povey, C Danpure, N Soldatov, N Soldatov, S Izumo, K Philipson, K Wenninger, I Komuro, B Saitta, R Timpl, M Chu, Unpublished, M M81836 H. ; Tenchini, L Marchetti, E Bossi, M Malcovati, R Lorenzetti, M Romkes, M Faletto, J Blaisdell, J Raucy, J Goldstein, M Romkes, M Faletto, J Blaisdell, J Raucy, J Goldstein, M Romkes, M Faletto, J Blaisdell, J Raucy, J Goldstein, M Romkes, M Faletto, J Blaisdell, J Raucy, J Goldstein, M Romkes, M Faletto, J Blaisdell, J Raucy, J Goldstein, P Nhamburo, S Kimura, O Mcbride, C Kozak, H Gelboin, F Gonzalez, D Kwiatkowski, J Unpublished ; Gilman, J Fleckner, H Rasmussen, J Justesen, E Meacci, M Taira, M Moos, C Smith, M Movsesian, E Degerman, P Belfrage, V Manganiello, J Renauld, F Houssiau, A Goethals, E Van Roost, J Van Snick, H, G, H Schooltink, T Stoyan, D Lenz, H Schmitz, T Hirano, T Kishimoto, P Heinrich, S Rose-John, G Adolf, B Fruehbeis, R Hauptmann, I Kalsner, I Maurer-Fogy, E Ostermann, E Patzelt, R Schwendenwein, W Sommergruber, A Zoephel, V Pascual, K Victor, D Lelsz, M Spellerberg, T Hamblin, K Thompson, I Randen, J Natvig, D Capra   +99 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

DNA polymerase λ autoinhibition is relieved via Ku interaction during non-homologous end joining. [PDF]

Nucleic Acids Res
Case BC, Scoccia L, Zhao Z, Loparo JJ.
europepmc   +1 more source

Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly

Advanced Science, EarlyView.
Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao, Juntao Hu, Juan Du, Shaokun Guo, Youming Hou, Zhihong Li   +5 more
wiley   +1 more source

Mixing features of transcription factors and genes enable accurate prediction of gene regulation relationships for unknown transcription factors. [PDF]

NAR Genom Bioinform
Okubo R, Morikura T, Hiki Y, Tokuoka Y, Kobayashi TJ, Yamada TG, Funahashi A.   +6 more
europepmc   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source