Results 251 to 260 of about 2,548,202 (389)

ISOLATION OF THE RICKETTSIAL INHIBITOR FROM AUTOCLAVED DIPHOSPHOPYRIDINE NUCLEOTIDE

, 1954
Sheldon Rosenberg, Marianna R. Bovarnick
openalex   +1 more source

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer‐Conjugated Aptamer

Advanced Healthcare Materials, EarlyView.
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang   +13 more
wiley   +1 more source

Decoding nature's grammar with DNA language models. [PDF]

Proc Natl Acad Sci U S A
Morrell PL, Pakhomov SV.
europepmc   +1 more source

A Histochemical Method for the Demonstration of Diphosphopyridine Nucleotide Diaphorase

, 1958
Marvin M. Nachlas, Donald G. Walker, Arnold M. Seligman   +2 more
openalex   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

A tubulin-binding protein that preferentially binds to GDP-tubulin and promotes GTP exchange. [PDF]

J Biol Chem
Yon WJ, Ha T, Zheng Y, Pedersen RTA.
europepmc   +1 more source

PHOTOSYNTHETIC PYRIDINE NUCLEOTIDE REDUCTASE

, 1958
Anthony San Pietro, Helga M. Lang
openalex   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Observing nucleotide flipping in DNA using indirect 2'-F nucleotide probes and 19F NMR. [PDF]

Nucleic Acids Res
Pidugu LS, Gustafson EE, Servius HW, Cook ME, Lee NC, Varney KM, Drohat AC.   +6 more
europepmc   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source