Results 281 to 290 of about 1,949,157 (309)

Estimating mutation rate and characterising single nucleotide de novo mutations in pigs. [PDF]

Genet Sel Evol
Rochus CM, Steensma MJ, Bink MCAM, Huisman AE, Harlizius B, Derks MFL, Crooijmans RPMA, Ducro BJ, Bijma P, Groenen MAM, Mulder HA.   +10 more
europepmc   +1 more source

NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

Advanced Science, EarlyView.
The study identifies a positive feed‐forward loop that intertwines DNA methylation regulator UHRF1 with Homeobox genes‐NKX2‐5/LHX1 via UMRs as a critical driver of ESCC. Pharmacological inhibition of UHRF1 and DNMT activity inhibits ESCC growth, which may represent a promising therapeutic approach to treat ESCC patients dependent on NKX2‐5/LHX1/UHRF1 ...
Xukun Li, Dandan Fan, Yong Li, Jian Yuan, Wanyuan Sun, Qinghao Zhu, Ling Qi, Xueling Wu, Jiahui Cai, Tongyang Gong, Ning Zhao, Jianzhong Su, Zhihua Liu, Hongyan Chen   +13 more
wiley   +1 more source

Editorial: Targeting nucleotide metabolism for enhancing antitumor immunity

Frontiers in Immunology
Jun Wu, Yu Rong, Tian Li, Cornelia M. Wilson, Yazhou He, Danqian Chen, Jin Han, Xingmei Zhang   +7 more
doaj   +1 more source

Genetic diversity and population structure of Aedes caspius in Iran. [PDF]

Sci Rep
Paksa A, Sanei-Dehkordi A, Shahabi S, Salim Abadi Y, Yousefi S.   +4 more
europepmc   +1 more source

A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges

Advanced Science, EarlyView.
A general model of inheriting changes that are acquired during the lifetime of individuals demonstrates tremendous benefits to the population, including escape from extinction in changing environments. Contrasting the model with experimental data shows that inheritance of acquired changes enables rapid adaptation to unforeseen challenges, and accounts ...
Dino Osmanović, Yitzhak Rabin, Yoav Soen   +2 more
wiley   +1 more source

Protein fluorescence of nicotinamide nucleotide-dependent dehydrogenases [PDF]

, 1972
Evans, RW, Gore, MG, Greenwood, C, Holbrook, BJJ, Reynolds, SJ, Yates, DW   +5 more
core  

Diversity of Hepatitis E Viruses in Rats in Yunnan Province and the Inner Mongolia Autonomous Region of China. [PDF]

Viruses
Li LL, Ma XH, Nan XW, Wang JL, Zhao J, Sun XM, Li JS, Zheng GS, Duan ZJ.   +8 more
europepmc   +1 more source

Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2

Advanced Science, EarlyView.
Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu, Yaochang Wei, Yuelin Li, Yiming Dou, YongQiang Yang, Hanghang Liu, Xiaoyan Wang, Zheng Wang, Jianmin Su, Yong Zhang, Yongsheng Wang   +10 more
wiley   +1 more source

Exploring Protein Expression Profiles in Lung Cancer Insufficient Microwave Ablation: Implications for Recurrence. [PDF]

Onco Targets Ther
Yan P, Yuan R, Li Z, Sun M.
europepmc   +1 more source

Assessment and Mitigation of CRISPR‐Cas9‐Induced Nontargeted Translocations

Advanced Science, EarlyView.
Various inverted repeat elements are dispersed throughout genomes. This study reveals that these elements can cause significant chromosomal rearrangements when CRISPR editing occurs in their proximity. The risk can be mitigated by incorporating inverted repeat‐homologous segments into the CRISPR system, which represents a promising strategy for ...
Zhiyang Hou, Qiyi Yi, Mengying Wu, Lijun Wu, Fanghua Li, Ting Wang, Po Bian   +6 more
wiley   +1 more source