Surface AMP deaminase 2 as a novel regulator modifying extracellular adenine nucleotide metabolism [PDF]
The FASEB Journal, 2021 Abstract Adenine nucleotides represent crucial immunomodulators in the extracellular environment. The ectonucleotidases CD39 and CD73 are responsible for the sequential catabolism of ATP to adenosine via AMP, thus promoting an anti‐inflammatory milieu induced by the “adenosine halo”.
Lisa Ehlers +8 more
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Rat porphobilinogen deaminase cDNA: nucleotide sequence of the erythropoletic form
Nucleic Acids Research, 1988 Anne-Caroline Stubnicer +2 more
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Single nucleotide editing without DNA cleavage using CRISPR/Cas9‐deaminase in the sea urchin embryo [PDF]
Developmental Dynamics, 2017 Background: A single base pair mutation in the genome can result in many congenital disorders in humans. The recent gene editing approach using CRISPR/Cas9 has rapidly become a powerful tool to replicate or repair such mutations in the genome. These approaches rely on cleaving DNA, while presenting unexpected risks.
Saba Shevidi +4 more
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Nucleotide Activation of Threonine Deaminase from Escherichia coli
Journal of Biological Chemistry, 1965 Masaharu Hirata +3 more
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Adenine Nucleotide Pool Perturbation Is a Metabolic Trigger for AMP Deaminase Inhibitor-Based Herbicide Toxicity [PDF]
Plant Physiology, 2007 AMP deaminase (AMPD) is essential for plant life, but the underlying mechanisms responsible for lethality caused by genetic and herbicide-based limitations in catalytic activity are unknown. Deaminoformycin (DF) is a synthetic modified nucleoside that is taken up by plant cells and 5'-phosphorylated into a potent transition state-type inhibitor of AMPD.
Richard L. Sabina +4 more
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Nucleotide sequence of the gene for threonine deaminase (ILV1) of Saccharomyces cerevisiae [PDF]
Carlsberg Research Communications, 1984 The 1,728 base pair coding region of theILV1 gene and the adjacent 777 base pair upstream and 261 base pair downstream regions were sequenced. The size of the polypeptide deduced from the coding region is larger than previously determined values for the molecular weight of threonine deaminase, suggesting that a peptide with a molecular weight of about ...
Morten C. Kielland‐Brandt +3 more
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Correction: A cytidine deaminase-like protein modulates pyrimidine nucleotide homeostasis in Trypanosoma brucei [PDF]
Scientific ReportsAna Moro-Bulnes +7 more
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Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes [PDF]
Cancers, 2019 Cancer genomes accumulate nucleotide sequence variations that number in the tens of thousands per genome. A prominent fraction of these mutations is thought to arise as a consequence of the off-target activity of DNA/RNA editing cytosine deaminases.
Igor B. Rogozin +8 more
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Chemical Science, 2022 In EDM-seq, the original C and 5mC in DNA are deaminated by eA3A to form U and T, both of which are read as T during sequencing. While the 5hmC is resistant to deamination by eA3A and is still read as C during sequencing.
Neng‐Bin Xie +6 more
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AMP Deaminase Inhibitors. 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series
Journal of Medicinal Chemistry, 2000 A series of N3-substituted coformycin aglycon analogues are described that inhibit adenosine 5'-monophosphate deaminase (AMPDA) or adenosine deaminase (ADA). The key steps involved in the preparation of these compounds are (1) treating the sodium salt of 6, 7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one (4) with an alkyl bromide or an alkyl mesylate to
Brett C. Bookser +3 more
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