Deaminase associated single nucleotide variants in blood and saliva-derived exomes from healthy subjects [PDF]
, 2019 AbstractBackgroundDeaminases play an important role in shaping inherited and somatic variants. Disease related SNVs are associated with deaminase mutagenesis and genome instability. Here, we investigate the reproducibility and variance of whole exome SNV calls in blood and saliva of healthy subjects and analyze variants associated with AID, ADAR ...
Nathan E. Hall +6 more
openalex +2 more sources
Myoadenylate deaminase deficiency. Functional and metabolic abnormalities associated with disruption of the purine nucleotide cycle. [PDF]
Journal of Clinical Investigation, 1984 To assess the role of the purine nucleotide cycle in human skeletal muscle function, we evaluated 10 patients with AMP deaminase deficiency (myoadenylate deaminase deficiency; MDD). 4 MDD and 19 non-MDD controls participated in an exercise protocol. The latter group was composed of a patient cohort (n = 8) exhibiting a constellation of symptoms similar
Richard L. Sabina +6 more
openalex +3 more sources
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2018 Cytosine and adenosine deamination events (DNA, RNA substrates) account for most codon-context Targeted Somatic Mutation (TSM) patterns observed in immunoglobulin (Ig) somatic hypermutation (SHM), and in cancer exomes following Ig-SHM-like responses.
Robyn A. Lindley, Nathan E. Hall
openalex +3 more sources
AMP Deaminase Inhibitors. 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series
Journal of Medicinal Chemistry, 2000 A series of N3-substituted coformycin aglycon analogues are described that inhibit adenosine 5'-monophosphate deaminase (AMPDA) or adenosine deaminase (ADA). The key steps involved in the preparation of these compounds are (1) treating the sodium salt of 6, 7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one (4) with an alkyl bromide or an alkyl mesylate to
Brett C. Bookser +3 more
openalex +3 more sources
Chemical Science, 2022 In EDM-seq, the original C and 5mC in DNA are deaminated by eA3A to form U and T, both of which are read as T during sequencing. While the 5hmC is resistant to deamination by eA3A and is still read as C during sequencing.
Neng‐Bin Xie +6 more
openalex +4 more sources
The RNA Binding Specificity of Human APOBEC3 Proteins Resembles That of HIV-1 Nucleocapsid. [PDF]
PLoS Pathogens, 2016 The APOBEC3 (A3) cytidine deaminases are antiretroviral proteins, whose targets include human immunodeficiency virus type-1 (HIV-1). Their incorporation into viral particles is critical for antiviral activity and is driven by interactions with the RNA ...
Ashley York +3 more
doaj +5 more sources
Rat porphobilinogen deaminase cDNA: nucleotide sequence of the erythropoletic form
Nucleic Acids Research, 1988 Anne-Caroline Stubnicer +2 more
openalex +5 more sources
Nucleotide Activation of Threonine Deaminase from Escherichia coli
Journal of Biological Chemistry, 1965 Masaharu Hirata +3 more
openalex +3 more sources
Correction: A cytidine deaminase-like protein modulates pyrimidine nucleotide homeostasis in Trypanosoma brucei [PDF]
Scientific ReportsAna Moro-Bulnes +7 more
openalex +2 more sources
Nucleotide sequence of thehemClocus encoding porpbobilinogen deaminase ofEscherichia coliK12
Nucleic Acids Research, 1986 Porphobilinogen deaminase, the product of the hemC locus in Escherichia coli K12, catalyses the tetrapolymerisation of porphobilinogen (PBG) into the hydroxymethylbilane, preuroporphyrinogen. The hemC locus has been subcloned from the Clarke and Carbon plasmid pLC41-4.
Steven Thomas, Peter M. Jordan
openalex +4 more sources