Results 21 to 30 of about 9,178 (231)
Deaminase associated single nucleotide variants in blood and saliva-derived exomes from healthy subjects [PDF]
, 2019 AbstractBackgroundDeaminases play an important role in shaping inherited and somatic variants. Disease related SNVs are associated with deaminase mutagenesis and genome instability. Here, we investigate the reproducibility and variance of whole exome SNV calls in blood and saliva of healthy subjects and analyze variants associated with AID, ADAR ...
Nathan E. Hall +6 more
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Proteus mirabilis amino acid deaminase: cloning, nucleotide sequence, and characterization of aad [PDF]
Journal of Bacteriology, 1995 Proteus, Providencia, and Morganella species produce deaminases that generate alpha-keto acids from amino acids. The alpha-keto acid products are detected by the formation of colored iron complexes, raising the possibility that the enzyme functions to secure iron for these species, which do not produce traditional siderophores. A gene encoding an amino
G Massad, Hui Zhao, Harry L. T. Mobley
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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2018 Cytosine and adenosine deamination events (DNA, RNA substrates) account for most codon-context Targeted Somatic Mutation (TSM) patterns observed in immunoglobulin (Ig) somatic hypermutation (SHM), and in cancer exomes following Ig-SHM-like responses.
Robyn A. Lindley, Nathan E. Hall
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Stem-loop structure preference for site-specific RNA editing by APOBEC3A and APOBEC3G [PDF]
PeerJ, 2017 APOBEC3A and APOBEC3G cytidine deaminases inhibit viruses and endogenous retrotransposons. We recently demonstrated the novel cellular C-to-U RNA editing function of APOBEC3A and APOBEC3G.
Shraddha Sharma, Bora E. Baysal
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Highly Efficient CRISPR-Mediated Base Editing in Sinorhizobium meliloti
Frontiers in Microbiology, 2021 Rhizobia are widespread gram-negative soil bacteria and indispensable symbiotic partners of leguminous plants that facilitate the most highly efficient biological nitrogen fixation in nature.
Longxiang Wang +6 more
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Myoadenylate deaminase deficiency. Functional and metabolic abnormalities associated with disruption of the purine nucleotide cycle. [PDF]
Journal of Clinical Investigation, 1984 To assess the role of the purine nucleotide cycle in human skeletal muscle function, we evaluated 10 patients with AMP deaminase deficiency (myoadenylate deaminase deficiency; MDD). 4 MDD and 19 non-MDD controls participated in an exercise protocol. The latter group was composed of a patient cohort (n = 8) exhibiting a constellation of symptoms similar
Richard L. Sabina +6 more
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Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]
, 2020 Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu +2 more
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Nature Communications, 2023 Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication conflicts (TRCs).
Aleix Bayona-Feliu +5 more
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Agricultural and Biological Chemistry, 1976 Tae-Shick Yu, Takuo Sakai, Shojiro Omata
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