Results 21 to 30 of about 9,136 (229)
Agricultural and Biological Chemistry, 1976 Tae-Shick Yu, Takuo Sakai, Shojiro Omata
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Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA. [PDF]
PLoS ONE, 2011 Editing deaminases have a pivotal role in cellular physiology. A notable member of this superfamily, APOBEC3G (A3G), restricts retroviruses, and Activation Induced Deaminase (AID) generates antibody diversity by localized deamination of cytosines in DNA.
Artem G Lada +6 more
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A split and inducible adenine base editor for precise in vivo base editing
Nature Communications, 2023 DNA base editors use deaminases fused to a programmable DNA-binding protein for targeted nucleotide conversion. However, the most widely used TadA deaminases lack post-translational control in living cells.
Hongzhi Zeng +9 more
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Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes. [PDF]
PLoS Genetics, 2015 Mutations in genomes of species are frequently distributed non-randomly, resulting in mutation clusters, including recently discovered kataegis in tumors. DNA editing deaminases play the prominent role in the etiology of these mutations.
Artem G Lada +6 more
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Molecular Therapy: Nucleic Acids, 2021 Base editors are RNA-guided deaminases that enable site-specific nucleotide transitions. The targeting scope of these Cas-deaminase fusion proteins critically depends on the availability of a protospacer adjacent motif (PAM) at the target locus and is ...
Lukas Villiger +5 more
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Stem-loop structure preference for site-specific RNA editing by APOBEC3A and APOBEC3G [PDF]
PeerJ, 2017 APOBEC3A and APOBEC3G cytidine deaminases inhibit viruses and endogenous retrotransposons. We recently demonstrated the novel cellular C-to-U RNA editing function of APOBEC3A and APOBEC3G.
Shraddha Sharma, Bora E. Baysal
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Highly Efficient CRISPR-Mediated Base Editing in Sinorhizobium meliloti
Frontiers in Microbiology, 2021 Rhizobia are widespread gram-negative soil bacteria and indispensable symbiotic partners of leguminous plants that facilitate the most highly efficient biological nitrogen fixation in nature.
Longxiang Wang +6 more
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Agricultural and Biological Chemistry, 1976 Tae-Shick Yu, Takuo Sakai, Shojiro Omata
openalex +3 more sources