Results 41 to 50 of about 9,136 (229)
Reduced APOBEC3H variant anti-viral activities are associated with altered RNA binding activities. [PDF]
PLoS ONE, 2012 APOBEC3H (A3H) is a member of the APOBEC3 family of proteins with varying activities against retroviruses and retrotransposons. The A3H gene contains several single nucleotide polymorphisms and up to seven haplotypes have been detected in humans ...
Anjie Zhen +4 more
doaj +1 more source
Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response. [PDF]
, 2011 Members of the APOBEC3 family of deoxycytidine deaminases counteract a broad range of retroviruses in vitro through an indirect mechanism that requires virion incorporation and inhibition of reverse transcription and/or hypermutation of minus strand ...
Barrett, Bradley S +7 more
core +4 more sources
Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution [PDF]
, 2015 Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA ...
Bertram, JG +7 more
core +1 more source
Genome Biology, 2022 Background The high-activity adenine base editors (ABEs), engineered with the recently-developed tRNA adenosine deaminases (TadA8e and TadA9), show robust base editing activity but raise concerns about off-target effects.
Shaofang Li +4 more
doaj +1 more source
Formation and degradation of deoxyadenosine nucleotides in inherited adenosine deaminase deficiency
Bioscience Reports, 1982 dATP, dADP, and dAMP equalled or exceeded the depleted levels of ATP, ADP, and AMP in erythrocytes from two children with adenosine deaminase (ADA; EC 3.5.4.4) deficiency. dATP and dADP were identified in the mononuclear cells of only one child. The levels of deoxyadenosine compounds fell dramatically after enzyme replacement therapy and were no longer
H A, Simmonds +4 more
openaire +2 more sources
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. [PDF]
, 2015 Background: ADAR enzymes convert adenosines to inosines within double-stranded RNAs, including microRNA (miRNA) precursors, with important consequences on miRNA retargeting and expression.
Alon, S +10 more
core +2 more sources
Frontiers in Neuroscience, 2012 RNA editing by adenosine deaminases that act on RNA converts adenosines to inosines in coding and non-coding regions of mRNAs. Inosines are interpreted as guanosines and hence, this type of editing can change codons, alter splice patterns, or influence ...
Aamira eTariq, Michael F Jantsch
doaj +1 more source
Transcription as a Threat to Genome Integrity [PDF]
, 2016 Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés +1 more
core +1 more source
Genome-wide identification and analysis of A-to-I RNA editing events in bovine by transcriptome sequencing. [PDF]
PLoS ONE, 2018 RNA editing increases the diversity of the transcriptome and proteome. Adenosine-to-inosine (A-to-I) editing is the predominant type of RNA editing in mammals and it is catalyzed by the adenosine deaminases acting on RNA (ADARs) family.
Mohammad Reza Bakhtiarizadeh +2 more
doaj +1 more source
Journal of Developmental Biology, 2023 Differential RNA editing by adenosine deaminases that act on RNA (ADARs) has been implicated in several neurological disorders, including Parkinson’s disease (PD).
Lindsey A. Starr +6 more
doaj +1 more source