Results 61 to 70 of about 48,126 (189)

Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease

Molecules, 2016
Nucleoside/nucleotide analogs that lack the 3′-hydroxy group are widely utilized for HIV therapy. These chain-terminating nucleoside analogs (CTNAs) block DNA synthesis after their incorporation into growing DNA, leading to the antiviral effects. However,
Junpei Yamamoto, Chiaki Takahata, Isao Kuraoka, Kouji Hirota, Shigenori Iwai   +4 more
doaj   +1 more source

ERCC1 Expression as a Predictor of Survival After Operation in Stage I Non-small Cell Lung Cancer Patients

Chinese Journal of Lung Cancer, 2010
Background and objective Proteins of the nucleotide excision repair pathway can repair DNA damage. The excision repair cross-complementing (ERCC) gene family reduce damagement of DNA by nucleotide excision and repair.
Jinchen SHAO, Jie ZHANG, Zhengping DING
doaj  

Ancestral Graph with Bias in Gene Conversion [PDF]

J. Appl. Probab. 50 (2013) 239-255, 2009
Gene conversion is a mechanism by which a double-strand break in a DNA molecule is repaired using a homologous DNA molecule as a template. As a result, one gene is 'copied and pasted' onto the other gene. It was recently reported that the direction of gene conversion appears to be biased towards G and C nucleotides.
arxiv  

DNA Damage Induced by Alkylating Agents and Repair Pathways

Journal of Nucleic Acids, 2010
The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. Simple methylating agents form adducts at N- and O-atoms.
Natsuko Kondo, Akihisa Takahashi, Koji Ono, Takeo Ohnishi   +3 more
doaj   +1 more source

Theoretical analysis of transcription process with polymerase stalling [PDF]

arXiv, 2015
Experimental evidences show that in gene transcription, RNA polymerase has the possibility to be stalled at certain position of the transcription template. This may be due to the template damage, or protein barriers. Once stalled, polymerase may backtrack along the template to the previous nucleotide to wait for the repair of the damaged site, or ...
arxiv  

Association between NER pathway gene polymorphisms and neuroblastoma risk in an eastern Chinese population

Molecular Therapy: Oncolytics, 2021
Neuroblastoma is a common childhood malignancy. Nucleotide excision repair (NER) polymorphisms have been shown to influence cancer susceptibility by modifying DNA repair efficiency.
Chunlei Zhou, Yizhen Wang, Lili He, Jinhong Zhu, Jinghang Li, Yingzi Tang, Haixia Zhou, Jing He, Haiyan Wu   +8 more
doaj  

Error-prone polymerase activity causes multinucleotide mutations in humans [PDF]

arXiv, 2013
About 2% of human genetic polymorphisms have been hypothesized to arise via multinucleotide mutations (MNMs), complex events that generate SNPs at multiple sites in a single generation. MNMs have the potential to accelerate the pace at which single genes evolve and to confound studies of demography and selection that assume all SNPs arise independently.
arxiv  

The molecular basis of nucleotide excision repair syndromes [PDF]

, 1994
D. Bootsma, Jan H.J. Hoeijmakers
openalex   +1 more source

Excision in Hopf cyclic homology [PDF]

arXiv, 2005
In this paper we show that both variants of the Hopf cyclic homology has excision under some natural homological conditions on the objects and the coefficient module.
arxiv  

Saccharomyces cerevisiae exonuclease-1 plays a role in UV resistance that is distinct from nucleotide excision repair [PDF]

, 1998
Jian Qiu
openalex   +1 more source