Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy [PDF]
, 2014 BRCA1, a key factor in homologous recombination repair may also regulate base excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of ATM and DNA-PKcs could be a promising strategy in breast cancer.
Abdel-Fatah, TMA +16 more
core +1 more source
Structure and mechanism of human DNA polymerase η [PDF]
, 2010 The variant form of the human syndrome xeroderma pigmentosum (XPV) is caused by a deficiency in DNA polymerase eta (Pol eta), a DNA polymerase that enables replication through ultraviolet-induced pyrimidine dimers.
A Alt +66 more
core +2 more sources
Nucleotide excision repair and human syndromes [PDF]
Carcinogenesis, 2000 DNA damage is implicated in cancer and aging, and several DNA repair mechanisms exist that safeguard the genome from these deleterious consequences. Nucleotide excision repair (NER) removes a wide diversity of lesions, the main of which include UV-induced lesions, bulky chemical adducts and some forms of oxidative damage.
de Boer, J (Jan), Hoeijmakers, Jan
openaire +3 more sources
Zuo1 supports G4 structure formation and directs repair toward nucleotide excision repair
Nature Communications, 2020 G4 structure-interacting proteins have been linked to DNA repair processes. Here the authors reveal that in yeast, Zuo1 associates with G4 structures and plays a role in repair pathway choice by promoting nucleotide excision repair and ultimately ...
Alessio De Magis +6 more
doaj +1 more source
Genomic and proteomic evidences unravel the UV-resistome of the poly-extremophile Acinetobacter sp. Ver3 [PDF]
, 2015 Ultraviolet radiation can damage biomolecules, with detrimental or even lethal effects for life. Even though lower wavelengths are filtered by the ozone layer, a significant amount of harmful UV-B and UV-A radiation reach Earth?s surface, particularly in
Carolina eBelfiore +6 more
core +1 more source
DNA Damage Repair: Predictor of Platinum Efficacy in Ovarian Cancer?
Biomedicines, 2021 Ovarian cancer (OC) is the seventh most common type of cancer in women worldwide. Treatment for OC usually involves a combination of surgery and chemotherapy with carboplatin and paclitaxel.
Dimitra T. Stefanou +4 more
doaj +1 more source
Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis [PDF]
, 2017 DNA interstrand crosslinks (ICLs) formed by antitumor agents, such as cisplatin or mitomycin C, are highly cytotoxic DNA lesions. Their repair is believed to be triggered primarily by the stalling of replication forks at ICLs in S-phase.
Enoiu, Milica +2 more
core
Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes [PDF]
, 2013 Nucleotide excision DNA repair is mechanistically conserved across all kingdoms of life. In prokaryotes, this multi-enzyme process requires six proteins: UvrA?D, DNA polymerase I and DNA ligase. To examine how UvrC locates the UvrB?
Aravind +63 more
core +2 more sources
Histone Displacement during Nucleotide Excision Repair [PDF]
International Journal of Molecular Sciences, 2012 Nucleotide excision repair (NER) is an important DNA repair mechanism required for cellular resistance against UV light and toxic chemicals such as those found in tobacco smoke. In living cells, NER efficiently detects and removes DNA lesions within the large nuclear macromolecular complex called chromatin.
Dinant, C. +2 more
openaire +3 more sources
Journal of Nucleic Acids, 2010 DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision ...
Rihito Morita +9 more
doaj +1 more source