Results 91 to 100 of about 280,333 (306)

Single nucleotide polymorphisms at the imprinted bovine insulin-like growth factor 2 (IGF2) locus are associated with dairy performance in Irish Holstein-Friesian cattle

, 2010
peer-reviewedThe imprinted insulin-like growth factor 2 gene (IGF2) encodes a fetal mitogenic hormone protein (IGF-II) and has previously been shown to be associated with performance in dairy cattle.
Berkowicz, Erik W, Magee, David A, Evans, R. D., Spillane, Charles, Mullen, Michael P., Sikora, Klaudia M, MacHugh, David E, Howard, Dawn J., Berry, Donagh   +8 more
core   +1 more source

When is an SNP not an SNP?

BioTechniques
Genomic duplications are important sources of structural change and gene innovation. In humans, the most recent and highly identical sequences (>90% homology, >1 kb long) are known as segmental duplications (SDs).
Shapour Jalilzadeh, Valerie Walker, Gary P Leggatt, Eli Hatchwell   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Single feature polymorphism discovery in rice.

PLoS ONE, 2007
The discovery of nucleotide diversity captured as single feature polymorphism (SFP) by using the expression array is a high-throughput and effective method in detecting genome-wide polymorphism.
Rajesh Kumar, Jing Qiu, Trupti Joshi, Babu Valliyodan, Dong Xu, Henry T Nguyen   +5 more
doaj   +1 more source

Nucleotide Sequence, Expression, and Chromosomal Mapping of Mrp and Mapping of Five Related Sequences

Genomics, 1993
We isolated and characterized a genomic clone for the mouse MARCKS-related protein, or MRP, also known as F52 and MacMARCKS. A 3699-bp plasmid contained 407 bp of 5'-flanking region, 186 bp of 5'-untranslated region, 600 bp of protein coding region, 784 bp of a single intron, 746 bp of 3'-untranslated region, and 976 bp of 3'-flanking region.
D F, Lobach, J M, Rochelle, M L, Watson, M F, Seldin, P J, Blackshear   +4 more
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Design of a high density SNP genotyping assay in the pig using SNPs identified and characterized by next generation sequencing technology [PDF]

, 2009
A systematic review of the literature was carried out to determine the evidence for the reliability and validity of the assessment methods used in veterinary medical education. The review followed the approach used by the Best Evidence Medical Education (
Rothschild, M. F., Clark Richard, Milan, D., Ramos Antonio M., Mark S Hansen, Martien A M Groenen, Affara, Nabeel A., Law, Andy S., Taylor, Jeremy F., Antonio M Ramos, Richard Clark, Andreia J Amaral, Schook Lawrence B., Megens, H.J.W.C., Max F. Rothschild, Crooijmans, Richard P.M.A., Bendixen, C., Taylor, J. F., Andy S Law, Denis Milan, Groenen, M.A.M., Robert D. Schnabel, Megens, H. J., Taylor Jeremy F., Hansen Mark S., Kerstens, H.H.D., Hansen, M. S., Crooijmans, R.P.M.A., Lawrence B Schook, Affara, N.A., Rohrer, Gary A., Tim P. L. Smith, Nabeel A. Affara, Tim P L Smith, Schnabel, R. D., Danny J Nonneman, Archibald Alan L., Law, A. S., Dehais Patrick, Nonneman Danny J., Law Andy S., Zhi-Liang Hu, Affara Nabeel A., Groenen, Martien A.M., Nonneman, Danny J., Archibald, A. L., Hedegaard Jakob, Ralph T Wiedmann, Danny J. Nonneman, Bendixen, Christian, Smith, T. P., Nabeel A Affara, Lawrence B. Schook, Hedegaard, Jakob, Crooijmans, R. P., Groenen, M. A., Carol Churcher, Hu, Z. L., Rohrer, G. A., Dehais, Patrice, Churcher, Carol, Clark, Richard, Megens, Hendrik-Jan, Hindrik H. Kerstens, Bendixen Christian, Beever, J. E., Churcher Carol, Amaral, Andreia J., Jeremy F Taylor, Zhi-Liang, Hu, Ralph T. Wiedmann, Gary A. Rohrer, Curt P. Van Tassell, Andy S. Law, Beever Jonathan E., Affara, N. A., Patrick Dehais, Rohrer Gary A., Dehais, P., Antonio M. Ramos, Gary A Rohrer, Ramos, A. M., Martien A. M. Groenen, Wiedmann, R. T., Kerstens, Hindrik H., Richard P. M. A. Crooijmans, Jakob Hedegaard, Churcher, C., Ramos, Antonio M., Hu Zhi-Liang, Kerstens Hindrik H., Alan L Archibald, Hansen, Mark S., Amaral, A. J., Schook, Lawrence B., Wiedmann Ralph T., Jonathan E. Beever, Milan Denis, Hedegaard, J., Christian Bendixen, Van Tassell Curt P., Mark S. Hansen, Kerstens, H. H., Andreia J. Amaral, Crooijmans Richard P. M. A., Groenen Martien A. M., Alan L. Archibald, Richard P M A Crooijmans, Amaral Andreia J., Jonathan E Beever, Rothschild, Max F., Rothschild Max F., Megens Hendrik-Jan, Smith, Tim P.L., Wiedmann, Ralph T., Jeremy F. Taylor, Clark, R., Milan, Denis, Archibald, Alan L., Nonneman, D. J., Hindrik H Kerstens, Schook, L. B., Hendrik-Jan Megens, Smith Tim P. L., Ramos, A., Van Tassell, Curt P., Beever, Jonathan E., Max F Rothschild, Schnabel Robert D., Robert D Schnabel, Amaral, A.J., Van Tassell, C. P., Curt P Van Tassell, Schnabel, Robert D.   +133 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Application of massive parallel sequencing to whole genome SNP discovery in the porcine genome [PDF]

, 2009
Background Although the Illumina 1 G Genome Analyzer generates billions of base pairs of sequence data, challenges arise in sequence selection due to the varying sequence quality.
Kerstens Hindrik HD, Heuven, H.C.M., Johan T den Dunnen, Henri CM Heuven, Andreia J Amaral, den Dunnen Johan T, Dibbits Bert, Groenen Martien AM, Heuven Henri CM, Megens, H.J.W.C., Amaral Andreia J, Megens Hendrik-Jan, Bert Dibbits, Martien AM Groenen, Groenen, M.A.M., Hendrik-Jan Megens, Dibbits, B.W., Dungen, J., den, Kerstens, H.H.D., Hindrik HD Kerstens, Richard PMA Crooijmans, Crooijmans, R.P.M.A., den Dungen, J., Crooijmans Richard PMA, Amaral, A.J.   +24 more
core   +1 more source

Genotyping by Sequencing in Almond: SNP Discovery, Linkage Mapping, and Marker Design

G3: Genes, Genomes, Genetics, 2018
In crop plant genetics, linkage maps provide the basis for the mapping of loci that affect important traits and for the selection of markers to be applied in crop improvement. In outcrossing species such as almond (Prunus dulcis Mill. D. A.
Shashi N. Goonetilleke, Timothy J. March, Michelle G. Wirthensohn, Pere Arús, Amanda R. Walker, Diane E. Mather   +5 more
doaj   +1 more source