Role of cyclic AMP and cyclic GMP as modulators of platelet cytosolic calcium
Journal of Clinical and Preventive Cardiology, 2016 Studies from our laboratory at the University of Minnesota as well as that of others have demonstrated that agonist-mediated receptor stimulation leads to the activation of phospholipase C and formation of second messengers, diacyl glycerol and inositol ...
Gundu H.R. Rao
doaj +1 more source
Au naturale: use of biologically derived cyclic di-nucleotides for cancer immunotherapy
Open Biology, 2021 Cyclic di-nucleotides (CDNs) are widespread second messenger signalling molecules that regulate fundamental biological processes across the tree of life.
Christopher M. Waters
doaj +1 more source
Probing ligand selectivity in pathogens
eLife, 2023 Why does protein kinase A respond to purine nucleosides in certain pathogens, but not to the cyclic nucleotides that activate this kinase in most other organisms?
Bryan VanSchouwen, Giuseppe Melacini
doaj +1 more source
The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected].. [PDF]
PLoS ONE, 2013 Adenosine 3', 5'-cyclic monophosphate (cAMP) and guanosine 3', 5'-cyclic monophosphate (cGMP) are well-studied second messengers that transmit extracellular signals into mammalian cells, with conserved functions in various other species such as ...
Ulrike Beckert +6 more
doaj +1 more source
Frontiers in Microbiology, 2022 Streptococcus suis and Streptococcus agalactiae evade the innate immune system of the infected host by mechanisms mediated by cell wall-anchored proteins: SntA and CdnP, respectively.
Alicia Cabezas +6 more
doaj +1 more source
Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides*
Journal of Biological Chemistry, 2015 Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating electrical activity in the heart and brain.
H. DeBerg +4 more
semanticscholar +1 more source
Time Course of the Increase in the Myocardial Slow Inward Current after a Photochemically Generated Concentration Jump of Intracellular cAMP [PDF]
, 1983 Voltage-clamped atrial trabeculae from bullfrog hearts were exposed to membrane-permeant photolyzable o-nitrobenzyl esters of cAMP and cGMP. UV flashes produced intracellular concentration jumps of cAMP or cGMP. With the cAMP derivative, flashes resulted
Engels, Joachim +3 more
core +1 more source
Establishing a sensitive fluorescence-based quantification method for cyclic nucleotides
BMC Biotechnology, 2020 Background Approximately 40% of prescribed drugs exert their activity via GTP-binding protein-coupled receptors (GPCRs). Once activated, these receptors cause transient changes in the concentration of second messengers, e.g., cyclic adenosine 3′,5 ...
Nadine Gruteser +9 more
doaj +1 more source
C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels. [PDF]
PLoS ONE, 2013 Kv11.1 potassium channels are important for regulation of the normal rhythm of the heartbeat. Reduced activity of Kv11.1 channels causes long QT syndrome type 2, a disorder that increases the risk of cardiac arrhythmias and sudden cardiac arrest.
Chai Ann Ng +5 more
doaj +1 more source
Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels [PDF]
, 2001 Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and ...
A Dietz +22 more
core +2 more sources