Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons [PDF]
, 2015 We describe here a detailed protocol for the synthesis of ribonucleotides specifically deuterated at each ribose carbon atom. We synthesized 20 specifically deuterated ribonucleotides: ATP, CTP, GTP, and UTP, each of which contained one of five ...
Azad, Robert +2 more
core +2 more sources
mBio, 2016 Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gene I [RIG-I]-like) and membrane-bound (Toll-like) pattern recognition receptors to activate innate immune signaling.
Ann F Durbin +3 more
semanticscholar +1 more source
A flexible model-based framework for robust estimation of mutational signatures [PDF]
arXiv, 2022 Somatic mutations in cancer can be viewed as a mixture distribution of several mutational signatures, which can be inferred using non-negative matrix factorization (NMF). Mutational signatures have previously been parametrized using either simple mono-nucleotide interaction models or general tri-nucleotide interaction models. We describe a flexible and
arxiv
Discovering and Mapping the Modified Nucleotides That Comprise the Epitranscriptome of mRNA.
Cold Spring Harbor Perspectives in Biology, 2019 SUMMARYAn important mechanism of gene expression regulation is the regulated modification of nucleotides in messenger RNA (mRNA). These modified nucleotides affect mRNA translation, stability, splicing, and other processes.
B. Linder, S. Jaffrey
semanticscholar +1 more source
Advances in Space Research, 1986 There has been much speculation about the types of molecules that were present in the first living forms. Recent discoveries show that RNA is a more versatile molecule than was previously believed, but whether it was ever able, for example, to synthesize its own monomers from available precursors is not yet known.
D. A. Usher, M.C. Needels
openaire +3 more sources
Comment on "Characterization of the tunneling conductance across DNA bases" [PDF]
, 2007 In a recent article, Zikic {\it et al.} [Phys. Rev. E {\bf 74}, 011919 (2006)] present first-principles calculations of the DNA nucleotides electrical conductance.
Di Ventra, Massimiliano +2 more
core +2 more sources
Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]
, 2000 The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Faussner, Alexander +1 more
core +1 more source
Oocyte maturation and quality: role of cyclic nucleotides.
Reproduction, 2016 The cyclic nucleotides, cAMP and cGMP, are the key molecules controlling mammalian oocyte meiosis. Their roles in oocyte biology have been at the forefront of oocyte research for decades, and many of the long-standing controversies in relation to the ...
R. Gilchrist +9 more
semanticscholar +1 more source
Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions
Nature Biotechnology, 2016 Massively parallel reporter assays (MPRAs) enable nucleotide-resolution dissection of transcriptional regulatory regions, such as enhancers, but only few regions at a time.
J. Ernst +6 more
semanticscholar +1 more source
Cryptic Variation in the Human Mutation Rate [PDF]
, 2009 The mutation rate is known to vary between adjacent sites within the human genome as a consequence of context, the most well-studied example being the influence of CpG dinucelotides.
Eyre-Walker, Adam +2 more
core +3 more sources