Results 61 to 70 of about 878,332 (327)

Identifizierung und Charakterisierung eines neuen Bindeproteins für zyklische Nukleotide [PDF]

, 2007
Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate are important intracellular messengers. Binding of cyclic nucleotides controls the activity of protein kinases, ion channels and guanine-nucleotide-exchange factors in many cells ...
Debowski, Katharina
core  

Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes. [PDF]

, 2019
BackgroundGeneral translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states.
A Battle, A Dana, A Kozomara, A Radhakrishnan, A Reyes, AG Hinnebusch, AG Hinnebusch, AO Subtelny, AV Pisarev, CDS Duncan, CJ Shoemaker, CL Simms, D Fell, D Ray, D Weinberg, DH Mathews, DR Cavener, DR Groebe, EM Novoa, F Sinturel, GL Chew, Guo-Liang Chew, GW Li, H Firczuk, H Gingold, H Gingold, H Guo, H Kacser, J Sponer, JD Blair, Jingyi Jessica Li, JJ Li, JJ Li, JJ Li, JT Cuperus, KA Cottrell, LD Fernades, M dos Reis, M Gonzalez-Porta, M Kozak, M Lynch, Mark Douglas Biggin, Mary K. Thompson, MF Princiotta, MF Rojas-Duran, MJ Liu, MW Jones-Rhoades, ND Sen, P Janich, P Shah, PN Borer, PY Hsu, R Lorenz, R Tunney, R Zhang, S Dvir, S Nakagawa, SA Lima, SJ Marygold, T Ben-Yehezkel, T Tuller, T Tuller, T von der Haar, T Xia, TG Johnstone, V Castelo-Szekely, V Presnyak, WL Noderer, Y Seol, Y Zarai, YV Svitkin, Z Bloom-Ackermann   +71 more
core   +3 more sources

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Kappa casein gen (CSN3) in horse: genetic variability in exon 1 and 4

Acta Agriculturae Slovenica, 2006
Kappa casein (κ-CN) is milk protein that determines the size and specific function of the casein micelles, and its clevage by chymosine is responsible for milk coagulation.
Sebastijan HOBOR, Tanja KUNEJ, Tina LENASI, Peter DOVČ   +3 more
doaj   +1 more source

Substantial regional variation in substitution rates in the human genome: importance of GC content, gene density and telomere-specific effects [PDF]

, 2005
This study presents the first global, 1 Mbp level analysis of patterns of nucleotide substitutions along the human lineage. The study is based on the analysis of a large amount of repetitive elements deposited into the human genome since the mammalian ...
Arndt, Peter F, Hwa, Terence, Petrov, Dmitri A   +2 more
core  

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

A machine learning-based strategy to elucidate the identification of antibiotic resistance in bacteria

Frontiers in Antibiotics
Microorganisms, crucial for environmental equilibrium, could be destructive, resulting in detrimental pathophysiology to the human host. Moreover, with the emergence of antibiotic resistance (ABR), the microbial communities pose the century’s largest ...
K. T. Shreya Parthasarathi, K. T. Shreya Parthasarathi, Kiran Bharat Gaikwad, Kiran Bharat Gaikwad, Shruthy Rajesh, Shweta Rana, Akhilesh Pandey, Akhilesh Pandey, Harpreet Singh, Jyoti Sharma, Jyoti Sharma   +10 more
doaj   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Light-Assisted Formation of Nucleosides and Nucleotides from Formamide in the Presence of Cerium Phosphate

Life
The abiotic formation of nucleotides from small, simple molecules is of large interest in the context of elucidating the origin of life scenario. In what follows, it is shown that nucleosides and nucleotides can be formed from formamide in a one-pot ...
Shoval Gilboa, Larisa Panz, Nitai Arbell, Yaron Paz   +3 more
doaj   +1 more source