Results 51 to 60 of about 1,516,986 (362)

Qs in the Nucleus [PDF]

Neuron, 2001
The polyglutamine diseases include at least nine neurodegenerative disorders. Accumulation of mutant protein with a toxic gain-in function in the nucleus appears to be the pathological basis of these diseases. In this issue of Neuron, La Spada et al. (2001) provide insight into the cell specificity of pathology for a polyglutamine disease by relating ...
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PHOTON EXCHANGE IN NUCLEUS–NUCLEUS COLLISIONS [PDF]

International Journal of Modern Physics A, 2003
The strong electromagnetic fields in peripheral heavy ion collisions give rise to photon–photon and photon–nucleus interactions. I present a general survey of the photon–photon and photon-hadron physics accessible in these collisions. Among these processes I discuss the nuclear fragmentation through the excitation of giant resonances, the Coulomb ...
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Dispersive contribution to the nucleus-nucleus potential [PDF]

Physical Review C, 1987
With a simple parametrization of the empirical imaginary potential depths, the real potential induced by a dispersion relation is calculated analytically for the elastic scattering of O16 by several target nuclei. Between 25e50 % of the real potential empirical depths can be attributed to this dispersive contribution when the energy approaches the ...
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Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Endoplasmic reticulum stress-related prognosis signature characterizes the immune landscape and predicts the prognosis of colon adenocarcinoma

Frontiers in Genetics
BackgroundColon adenocarcinoma (COAD) is characterized by high mortality and poor prognosis. Endoplasmic reticulum stress-related gene (ERSG) plays an indispensable role in the progression and immunotherapy of COAD.
Lichao Cao, Lichao Cao, Lichao Cao, Lichao Cao, Haoyang Dai, Haoyang Dai, Shangqing Wei, Shangqing Wei, Ying Ba, Ying Ba, Ying Ba, Fang Chen, Fang Chen, Fang Chen, Yingying Chen, Yingying Chen, Yingying Chen, Chendi Yu, Chendi Yu, Chendi Yu, Shenrui Zhang, Shenrui Zhang, Shenrui Zhang, Erfei Chen, Erfei Chen, Erfei Chen, Hezi Zhang, Hezi Zhang, Hezi Zhang   +28 more
doaj   +1 more source

Viruses in the Nucleus

Cold Spring Harbor Perspectives in Biology, 2021
Viral infection is intrinsically linked to the capacity of the virus to generate progeny. Many DNA and some RNA viruses need to access the nuclear machinery and therefore transverse the nuclear envelope barrier through the nuclear pore complex. Viral genomes then become chromatinized either in their episomal form or upon integration into the host ...
Lucic, B, de Castro, IJ, Lusic, M
openaire   +5 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current

Channels
L-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 pore-forming ...
Felipe Arancibia, Daniela De Giorgis, Franco Medina, Tamara Hermosilla, Felipe Simon, Diego Varela   +5 more
doaj   +1 more source