Results 71 to 80 of about 1,491,280 (348)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Cortical and Subcortical Contributions to Stop Signal Response Inhibition: Role of the Subthalamic Nucleus

Journal of Neuroscience, 2006
Suppressing an already initiated manual response depends critically on the right inferior frontal cortex (IFC), yet it is unclear how this inhibitory function is implemented in the motor system.
A. Aron, R. Poldrack
semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles

Frontiers in Neuroscience, 2020
Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its physiological functions are only partially understood. α-syn accumulation is associated with Parkinson’s disease, dementia with Lewy bodies, and multiple system ...
Luis D. Bernal-Conde, Luis D. Bernal-Conde, Rodrigo Ramos-Acevedo, Rodrigo Ramos-Acevedo, Mario A. Reyes-Hernández, Mario A. Reyes-Hernández, Andrea J. Balbuena-Olvera, Andrea J. Balbuena-Olvera, Ishbelt D. Morales-Moreno, Ishbelt D. Morales-Moreno, Rubén Argüero-Sánchez, Birgitt Schüle, Magdalena Guerra-Crespo, Magdalena Guerra-Crespo   +13 more
doaj   +1 more source

Mechanosensing by the nucleus: From pathways to scaling relationships

Journal of Cell Biology, 2017
The nucleus is linked mechanically to the extracellular matrix via multiple polymers that transmit forces to the nuclear envelope and into the nuclear interior.
Sangkyun Cho, J. Irianto, D. Discher
semanticscholar   +1 more source

Antiproton production in p-nucleus and nucleus-nucleus collisions

Physics Letters B, 1991
Abstract The production of antiprotons in proton-nucleus and nucleus-nucleus reactions is analyzed with respect to baryon-baryon production processes. The dynamical evolution of the phase-space distributions is treated on the basis of the Vlasov-Uehling-Uhlenbeck transport theory including explicitly pion, Δ(1232) and N∗(1400) degrees of freedom and ...
Ulrich Mosel, Wolfgang Cassing, G. Batko, Gy. Wolf, Koji Niita   +4 more
openaire   +2 more sources

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Kinds of nucleus for effective pearl cultivation of the pearl oysters, Pinctada fucata [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2007
Seeding is the most important aspect of pearl cultivation, and appropriate nucleus can determine the quality of a pearl : nacre secretion and accumulation around the nucleus.
Kanjanachatree, K., Piyathamrongrut, K., Inthoncharoen, J.   +2 more
doaj  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source