Results 71 to 80 of about 2,090,052 (356)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current

Channels
L-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 pore-forming ...
Felipe Arancibia, Daniela De Giorgis, Franco Medina, Tamara Hermosilla, Felipe Simon, Diego Varela   +5 more
doaj   +1 more source

The high energy frontier of ultrarelativistic nucleus-nucleus collisions [PDF]

, 2011
An outlook on physics at the high energy frontier of nucleus-nucleus collisions is presented, on the basis of the new results presented at Quark Matter 2011 by the LHC and RHIC experiments.
arxiv   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Nucleus-nucleus potential from identical-particle interference

, 2018
Based on the quantum interference between two-identical-nucleus scattering at energies around the Coulomb barrier, the barrier positions for $^{58}$Ni+$^{58}$Ni and $^{16}$O+$^{16}$O are extracted from Mott oscillations in the angular distributions ...
Lin, Chengjian, Liu, Min, Wang, Ning, Yang, Yongxu   +3 more
core   +1 more source

High energy factorization in nucleus-nucleus collisions [PDF]

, 2008
We derive a high energy factorization theorem for inclusive gluon production in A+A collisions. Our factorized formula resums i) all order leading logarithms (g^2 \ln(1/x_{1,2}))^n of the incoming partons momentum fractions, and ii) all contributions (g \
Gelis, Francois, Lappi, Tuomas, Venugopalan, Raju   +2 more
core   +5 more sources

Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins

eLife, 2019
Chromosomal DNA elements are organized into spatial domains within the eukaryotic nucleus. Sites undergoing DNA replication, high-level transcription, and repair of double-strand breaks coalesce into foci, although the significance and mechanisms giving ...
Haiyang Zhang, Meghan V Petrie, Yiwei He, Jared M Peace, Irene E Chiolo, Oscar M Aparicio   +5 more
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Topics on Hydrodynamic Model of Nucleus-Nucleus Collisions [PDF]

, 2004
A survey is given on the applications of hydrodynamic model of nucleus-nucleus collisons, focusing especially on i) the resolution of hydrodynamic equations for arbitrary configurations, by using the smoothed-particle hydrodynamic approach; ii) effects ...
Hama, Y., Kodama, T., Socolowski Jr, O.
core   +2 more sources

The study of quark-gluon matter in high-energy nucleus-nucleus collisions [PDF]

, 2012
A short overview is given on the study of hot matter produced in relativistic nucleus-nucleus collisions, with emphasis on recent measurements at the LHC.
arxiv   +1 more source