Results 71 to 80 of about 1,516,986 (362)

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

open access: yesEMBO Journal, 2012
The lysosome plays a key role in cellular homeostasis by controlling both cellular clearance and energy production to respond to environmental cues. However, the mechanisms mediating lysosomal adaptation are largely unknown.
C. Settembre   +12 more
semanticscholar   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

The manifestation of intonational focus in Castilian Spanish

open access: yesCatalan Journal of Linguistics, 2003
In this paper we study the phonological manifestation of various intonational focus domains in Castilian Spanish. We propose that downstep is one of the intonational signallers of focus in this language.
Mercedes Cabrera Abreu   +1 more
doaj   +1 more source

The Czech Plant Nucleus Workshop 2021

open access: yesBiologia Plantarum, 2022
The Czech Plant Nucleus Workshop 2021 (CPNW2021) took place during mid-September 2021 in Olomouc, Czech Republic. About 80 researchers and students working in the field of plant nuclear and chromosome biology in the Czech Republic gathered together to ...
A. PECINKA   +4 more
doaj   +1 more source

A Globin in the Nucleus! [PDF]

open access: yesJournal of Biological Chemistry, 2003
Cytoglobin and neuroglobin are recently discovered members of the globin family. In situ hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed ubiquitously in all analyzed tissues. In the present study, polyclonal antibodies were raised against both proteins and the distribution of them was studied by ...
Geuens, Eva   +5 more
openaire   +4 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Antiproton production in p-nucleus and nucleus-nucleus collisions

open access: yesPhysics Letters B, 1991
Abstract The production of antiprotons in proton-nucleus and nucleus-nucleus reactions is analyzed with respect to baryon-baryon production processes. The dynamical evolution of the phase-space distributions is treated on the basis of the Vlasov-Uehling-Uhlenbeck transport theory including explicitly pion, Δ(1232) and N∗(1400) degrees of freedom and ...
Ulrich Mosel   +4 more
openaire   +2 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Protein kinase FAM20C—when subcellular localization matters

open access: yesFEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

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