Results 81 to 90 of about 1,379,939 (300)

Bacterial Factors Targeting the Nucleus: The Growing Family of Nucleomodulins

Toxins, 2020
Pathogenic bacteria secrete a variety of proteins that manipulate host cell function by targeting components of the plasma membrane, cytosol, or organelles.
Hélène Bierne, Renaud Pourpre
doaj   +1 more source

Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease [PDF]

, 2001
The extent of synchronization within and between the nuclei of the basal ganglia is unknown in Parkinson's disease. The question is an important one because synchronization will increase postsynaptic efficacy at subsequent projection targets.
Peter Brown, Vincenzo Di Lazzaro, Oliviero, A, Insola, A, Antonio Oliviero, Di Lazzaro, V, Mazzone, P, Brown, P, Pietro Tonali, Tonali, P, Paolo Mazzone, Angelo Insola   +11 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Defining a role for the peduncolopontine tegmental nucleus in striatal outflow [PDF]

, 2012
The pedunculopontine tegmental nucleus (PPTg) lies within the pontomesencephalon and contains cholinergic and non-cholinergic neurones. It has extensive afferent and efferent connections throughout the brain.
Allen, Laura F.
core   +1 more source

The Nuclear Pore Complex: A Target for NS3 Protease of Dengue and Zika Viruses

Viruses, 2020
During flavivirus infection, some viral proteins move to the nucleus and cellular components are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of the nuclear-cytoplasmic transport, the nuclear pore complex (NPC ...
Luis Adrián De Jesús-González, Margot Cervantes-Salazar, José Manuel Reyes-Ruiz, Juan Fidel Osuna-Ramos, Carlos Noe Farfán-Morales, Selvin Noé Palacios-Rápalo, José Humberto Pérez-Olais, Carlos Daniel Cordero-Rivera, Arianna M. Hurtado-Monzón, Fernando Ruíz-Jiménez, Ana Lorena Gutiérrez-Escolano, Rosa María del Ángel   +11 more
doaj   +1 more source

Heavy flavors in nucleus-nucleus and proton-nucleus collisions [PDF]

EPJ Web of Conferences, 2016
A multi-step setup for heavy-flavor studies in high-energy nucleus-nucleus (AA) and proton-nucleus (pA) collisions is presented. The propagation of the heavy quarks in the medium is described in a framework provided by the relativistic Langevin equation, here solved using weak-coupling transport coefficients. Successively, the heavy quarks hadronize in
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Characterisation of cell death inducing Phytophthora capsici CRN effectors suggests diverse activities in the host nucleus

Frontiers in Plant Science, 2013
Plant-Microbe interactions are complex associations that feature recognition of Pathogen Associated Molecular Patterns by the plant immune system and dampening of subsequent responses by pathogen encoded secreted effectors.
Remco eStam, Remco eStam, Andrew James Mark Howden, Magdalena eDelgado Cerezo, Tiago Miguel Marques Monteiro Amaro, Graham Brian Motion, Graham Brian Motion, Jasmine ePham, Edgar eHuitema   +8 more
doaj   +1 more source

Posthatching development of synapses in the neuropil of nucleus rotundus of the zebra finch: a quantitative electron microscopic study [PDF]

, 1986
Nixdorf B, Bischof H-J. Posthatching development of synapses in the neuropil of nucleus rotundus of the zebra finch: a quantitative electron microscopic study. The Journal of Comparative Neurology.
Nixdorf, Barbara, Barbara Nixdorf, Hans‐Joachim Bischof, Bischof, Hans-Joachim   +3 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source