Results 71 to 80 of about 15,407,870 (296)

Bird species diversity in the Atlantic Forest of Brazil is not explained by the Mid-domain Effect

Zoologia (Curitiba), 2012
The Atlantic Forest is an excellent case study for the elevational diversity of birds, and some inventories along elevational gradients have been carried out in Brazil.
Vagner Cavarzere, Luís Fábio Silveira
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Geometric randomization of real networks with prescribed degree sequence

New Journal of Physics, 2019
We introduce a model for the randomization of complex networks with geometric structure. The geometric randomization (GR) model assumes a homogeneous distribution of the nodes in a hidden similarity space and uses rewirings of the links to find ...
Michele Starnini, Elisenda Ortiz, M Ángeles Serrano   +2 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

An Efficient Null Model for Conformational Fluctuations in Proteins [PDF]

Structure, 2012
Protein dynamics play a crucial role in function, catalytic activity, and pathogenesis. Consequently, there is great interest in computational methods that probe the conformational fluctuations of a protein. However, molecular dynamics simulations are computationally costly and therefore are often limited to comparatively short timescales.
Harder, Tim, Borg, Mikael, Bottaro, Sandro, Boomsma, Wouter, Olsson, Simon, Ferkinghoff-Borg, Jesper, Hamelryck, Thomas   +6 more
openaire   +4 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Optimized Null Model for Protein Structure Networks

PLoS ONE, 2009
Much attention has recently been given to the statistical significance of topological features observed in biological networks. Here, we consider residue interaction graphs (RIGs) as network representations of protein structures with residues as nodes and inter-residue interactions as edges. Degree-preserving randomized models have been widely used for
Milenkovic, Tijana, Filippis, Ioannis, Lappe, Michael, Przulj, Natasa   +3 more
openaire   +6 more sources

Mate Choice and Null Models [PDF]

Philosophy of Science, 2020
Biologists have proposed a variety of explanations for extravagant sexual displays, and controversies over explanations define the history of sexual selection research. Recently, Richard Prum has defended Darwin’s idea that the evolution of sexual displays is driven by arbitrary and nonadaptive preferences of potential mates.
openaire   +1 more source

A Fractal Landscape Realizer for Generating Synthetic Maps

Ecology and Society, 2002
A fractal landscape realizer has been developed that generates synthetic landscape maps to user specifications. The alternative landscape realizations are not identical to the actual maps after which they are patterned, but are similar statistically (i.e.
William Hargrove, Forrest M. Hoffman, Paul M. Schwartz   +2 more
doaj   +1 more source