Results 71 to 80 of about 16,000,889 (256)
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Recently, the interest to polynomial representations of functions over finite fields and over finite rings is being increased. Complexity of those representations is widely studied.
A. Kazimirov, S. Reymerov
doaj
The phase sensitivity of a fully quantum three-mode nonlinear interferometer
We study a nonlinear interferometer consisting of two consecutive parametric amplifiers, where all three optical fields (pump, signal and idler) are treated quantum mechanically, allowing for pump depletion and other quantum phenomena. The interaction of
Jefferson Flórez +5 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
We report an experimental demonstration of resonance fluorescence in a two-level superconducting artificial atom under two driving fields coupled to a detuned cavity.
Xinhui Ruan +13 more
doaj +1 more source
A strategy to unveil transient sources of ultra-high-energy cosmic rays
Transient generation of ultra-high-energy cosmic rays (UHECRs) has been motivated from promising candidates of UHECR sources such as gamma-ray bursts, flares of active galactic nuclei, and newly born neutron stars and magnetars.
Takami Hajime
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
ON SOME DIFFERENCES BETWEEN NUMBER FIELDS AND FUNCTION FIELDS
International audienceThe analogy between the arithmetic of varieties over number fields and the arithmetic of varieties over function fields is a leading theme in arithmetic geometry. This analogy is very powerful but there are some gaps.
Gasbarri, Carlo
core +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source

