Results 51 to 60 of about 1,082,587 (269)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

An Implementation of the Number Field Sieve [PDF]

open access: yesExperimental Mathematics, 1996
The Number Field Sieve (NFS) is the asymptotically fastest known factoring algorithm for large integers. This article describes an implementation of the NFS, including the choice of two quadratic polynomials, both classical sieving and a special form of lattice sieving (line sieving), the block Lanczos method and a new square root algorithm.
openaire   +3 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Units in families of totally complex algebraic number fields

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2004
Multidimensional continued fraction algorithms associated with GLn(ℤk), where ℤk is the ring of integers of an imaginary quadratic field K, are introduced and applied to find systems of fundamental units in families of totally complex algebraic number ...
L. Ya. Vulakh
doaj   +1 more source

About the Entropy of a Natural Number and a Type of the Entropy of an Ideal

open access: yesEntropy, 2023
In this article, we find some properties of certain types of entropies of a natural number. We are studying a way of measuring the “disorder” of the divisors of a natural number. We compare two of the entropies H and H¯ defined for a natural number.
Nicuşor Minculete, Diana Savin
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Invariants of number fields related to central embedding problems

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1990
Every central embedding problem over a number field becomes solvable after enlarging its kernel in a certain way. We show that these enlargements can be arranged in a universal way.
H. Opolka
doaj   +1 more source

The unit group of some fields of the form $\mathbb{Q}(\sqrt2, \sqrt{p}, \sqrt{q}, \sqrt{-l})$ [PDF]

open access: yesMathematica Bohemica
Let $p$ and $q$ be two different prime integers such that $p\equiv q\equiv3\pmod8$ with $(p/q)=1$, and $l$ a positive odd square-free integer relatively prime to $p$ and $q$.
Moha Ben Taleb El Hamam
doaj   +1 more source

Home - About - Disclaimer - Privacy