Results 71 to 80 of about 1,082,587 (269)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Improved bounds on number fields of small degree
Discrete AnalysisImproved bounds on number fields of small degree, Discrete Analysis 2024:19, 24 pp. Each number field $K$, or finite degree extension of $\mathbb Q$, has an associated rational integer, its discriminant $\mathrm{Disc}(K)$, which measures the size of ...
Theresa C. Anderson +7 more
doaj +1 more source
MathematicsBased on the representation of finite field elements by fractions, an algorithmic procedure is introduced to define a field Q(p)=Qp,+,⋅ of discrete rational numbers.
Carmine Castaldo
doaj +1 more source
, 2016 The canonical covering maps from Hurwitz varieties to configuration varieties are important in algebraic geometry. The scheme-theoretic fiber above a rational point is commonly connected, in which case it is the spectrum of a Hurwitz number field. We study many examples of such maps and their fibers, finding number fields whose existence contradicts ...
openaire +3 more sources
Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Average Analytic Ranks of Elliptic Curves over Number Fields
Forum of Mathematics, SigmaWe give a conditional bound for the average analytic rank of elliptic curves over an arbitrary number field. In particular, under the assumptions that all elliptic curves over a number field K are modular and have L-functions which satisfy the ...
Tristan Phillips
doaj +1 more source
HT90 and “simplest” number fields
Illinois Journal of Mathematics, 2011 34 pages, no figures, uses href for internal cross-references.
openaire +4 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source