Results 71 to 80 of about 4,829,005 (281)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Constructive Realization of the Rational, Real, and Complex Numbers via Sequences over Finite Fields of Increasing Order

Mathematics
Based on the representation of finite field elements by fractions, an algorithmic procedure is introduced to define a field Q(p)=Qp,+,⋅ of discrete rational numbers.
Carmine Castaldo
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Improved bounds on number fields of small degree

Discrete Analysis
Improved bounds on number fields of small degree, Discrete Analysis 2024:19, 24 pp. Each number field $K$, or finite degree extension of $\mathbb Q$, has an associated rational integer, its discriminant $\mathrm{Disc}(K)$, which measures the size of ...
Theresa C. Anderson, Ayla Gafni, Kevin Hughes, Robert J. Lemke Oliver, David Lowry-Duda, Frank Thorne, Jiuya Wang, Ruixiang Zhang   +7 more
doaj   +1 more source

Number fields with prescribed norms

, 2018
We study the distribution of extensions of a number field $k$ with fixed abelian Galois group $G$, from which a given finite set of elements of $k$ are norms. In particular, we show the existence of such extensions.
Frei, Christopher, Harpaz, with an appendix by Yonatan, Loughran, Daniel, Newton, Rachel, Wittenberg, Olivier   +4 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Average Analytic Ranks of Elliptic Curves over Number Fields

Forum of Mathematics, Sigma
We give a conditional bound for the average analytic rank of elliptic curves over an arbitrary number field. In particular, under the assumptions that all elliptic curves over a number field K are modular and have L-functions which satisfy the ...
Tristan Phillips
doaj   +1 more source

On some differences between number fields and function fields

, 2016
The analogy between the arithmetic of varieties over number fields and the arithmetic of varieties over function fields is a leading theme in arithmetic geometry. This analogy is very powerful but there are some gaps.
Gasbarri, Carlo
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Number fields unramified away from 2

, 2006
We consider finite extensions of the rationals which are unramified except for at 2 and infinity.
Jones, John W.
core   +2 more sources