Results 91 to 100 of about 5,030,102 (295)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Approximating the Solution Stochastic Process of the Random Cauchy One-Dimensional Heat Model
Abstract and Applied Analysis, 2016 This paper deals with the numerical solution of the random Cauchy one-dimensional heat model. We propose a random finite difference numerical scheme to construct numerical approximations to the solution stochastic process.
A. Navarro-Quiles +3 more
doaj +1 more source
Simple numerical example for load evolution model.
Simple numerical example for load evolution model.
Yueqi Fan (17781401)
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A new example of deficiency one groups
, 2010 Bu çalışma, 19-25 Eylül 2010 tarihleri arasında Rhodes[Yunanistan]’da düzenlenen International Conference on Numerical Analysis and Applied Mathematics’da bildiri olarak sunulmuştur.The main purpose of this paper is to present a new example of ...
Ateş, Fırat +3 more
core +2 more sources
On the Problem of Constructing Routes, Part II: Methodology and Numerical Example
Transport and Telecommunication, 2017 We consider a periodic aviation schedule which is a finite collection of flights with given arrival/departure times. For this schedule, we solve the problem of finding the minimal number of aircrafts needed to carry out the flights.
Linis V. K., Maksim M. S.
doaj +1 more source
Constructed numerical example.
, 2015 Assumed sensitivity and specificity of the three tests: index test, 80% and 90%; test A, 50% and 100%; test B, 85% and 85%. Comparing the index test to a CRS = (fever) AND ((test A positive) OR (test B positive)).
Helen L. Storey (826094) +5 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source