Results 41 to 50 of about 2,030,934 (244)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A multi-level interface model for damaged masonry [PDF]

, 2013
The aim of the present work is to propose a new micro-mechanical model in the context of the deductive approach used to derive interface models. This model, based on a previous study introduced previously by A. Rekik and F.
E. Sacco, Lebon, Frédéric, Sacco, Elio, Welemane, Hélène, Raffa, Maria Letizia, H. Welemane, F. Lebon, M. L. Raffa   +7 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Numerical Homogenization for the Calculation of Eddy Current Losses in a Laminated Open Core

IEEE Access
Eddy currents are decoupled into narrow eddy currents, induced by the magnetic flux tangential to the laminations, and planar eddy currents, induced by the magnetic flux perpendicular to the laminations.
Stjepan Frljic, Ana Drandic, Bojan Trkulja   +2 more
doaj   +1 more source

DIFFUSION PIECEWISE HOMOGENIZATION VIA FLUX DISCONTINUITY RATIOS

Nuclear Engineering and Technology, 2013
We analyze piecewise homogenization with flux-weighted cross sections and preservation of averaged currents at the boundary of the homogenized domain.
RICHARD SANCHEZ, GIORGIO DANTE, IGOR ZMIJAREVIC   +2 more
doaj   +1 more source

Intensity Segmentation of the Human Brain with Tissue dependent Homogenization [PDF]

, 2002
High-precision segmentation of the human cerebral cortex based on T1-weighted MRI is still a challenging task. When opting to use an intensity based approach, careful data processing is mandatory to overcome inaccuracies.
Rodenacker, K., Auer, Dorothee P., Hahn, Klaus   +2 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Recent developments in numerical homogenization

Computer Assisted Methods in Engineering and Science, 2017
This paper deals with homogenization of non linear fibre-reinforced composites in the coupled thermomechanical field. For this kind of structures, i.e.
Daniela P. Boso, Marek Lefik, Bernhard A. Schrefler   +2 more
doaj  

Response Surfaces in the Numerical Homogenization of Non-Linear Porous Materials

Engineering Transactions, 2019
The paper deals with the numerical homogenization of structures made of non-linear porous material. Material non-linearity causes a significant increase in computational costs for numerical homogenization procedure. An application of the response surface
Witold BELUCH, Marcin HATŁAS
doaj   +1 more source

Parallel identification of voids in a microstructure using the boundary element method and the bioinspired algorithm [PDF]

Computer Methods in Materials Science, 2013
The problem of identification of the size of a void in a microscale on the basis of the homogenized material parameters is studied in this work. A three-dimensional unit-cell model of a porous microstructure is modelled and analyzed by the boundary ...
Wacław Kuś, Radosław Górski
doaj   +1 more source