Results 51 to 60 of about 2,030,934 (244)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Micromechanics of rock damage: Advances in the quasi-brittle field

Journal of Rock Mechanics and Geotechnical Engineering, 2017
Constitutive models play an essential role in numerical modeling and simulation of nonlinear deformation, progressive damage and failure of rock-like materials and structures.
Qizhi Zhu, Jianfu Shao
doaj   +1 more source

An extension theorem in SBV and an application to the homogenization of the Mumford-Shah functional in perforated domains [PDF]

, 2011
The aim of this paper is to prove the existence of extension operators for SBV functions from periodically perforated domains.
Filippo Cagnetti (4464373), F. Cagnetti, SCARDIA L, Cagnetti, F., CAGNETTI F, Scardia, L., Cagnetti, F, L. Scardia, Scardia, L Lucia, L Scardia (16163129)   +9 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Multiscale modeling of composite cylindrical tank

Data in Brief, 2018
This article provides the useful data information on multiscale modeling of liquid storage laminated composite cylindrical tank under seismic load. The investigation process is divided into three levels. Within the numerical homogenization, the hexagonal
Eva Kormanikova, Kamila Kotrasova
doaj   +1 more source

Proper generalized decomposition of time-multiscale models [PDF]

, 2011
Models encountered in computational mechanics could involve many time scales. When these time scales cannot be separated, one must solve the evolution model in the entire time interval by using the finest time step that the model implies.
CHINESTA SORIA, Francisco, DOBLARÉ, Manuel, Chinesta, Francisco, CUETO, Elias, Amine Ammar, Francisco Chinesta, Manuel Doblaré, Elías Cueto, AMMAR, Amine   +8 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Multi-Step Mechanical and Thermal Homogenization for the Warpage Estimation of Silicon Wafers

Micromachines
In response to the increasing demand for high-performance capacitors, with a simultaneous emphasis on minimizing their physical size, a common practice involves etching deep vias and coating them with functional layers to enhance operational efficiency ...
Zhouyi Xiang, Min Chen, Yonghui Deng, Songhua Huang, Sanli Liu, Ji Li   +5 more
doaj   +1 more source

Homogenization simulation of material extruded lattice structures

Heliyon, 2023
The paper investigates the mechanical behavior of structural elements of a material extruded component using a multiscale analysis based on a homogenization method.
Roberto Spina, Maria Grazia Guerra, Silvia Di Rosa, Giulio Morandina   +3 more
doaj   +1 more source

Homogenization of two fluid flow in porous media

, 2015
The macroscopic behavior of air and water in porous media is often approximated using Richards’ equation for the fluid saturation and pressure. This equation is parametrized by the hydraulic conductivity and water release curve.
Roose, T., Daly, K. R.
core   +1 more source