Results 71 to 80 of about 65,683 (285)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Multi-Step Mechanical and Thermal Homogenization for the Warpage Estimation of Silicon Wafers

Micromachines
In response to the increasing demand for high-performance capacitors, with a simultaneous emphasis on minimizing their physical size, a common practice involves etching deep vias and coating them with functional layers to enhance operational efficiency ...
Zhouyi Xiang, Min Chen, Yonghui Deng, Songhua Huang, Sanli Liu, Ji Li   +5 more
doaj   +1 more source

An Equation-Free Approach for Second Order Multiscale Hyperbolic Problems in Non-Divergence Form

, 2018
The present study concerns the numerical homogenization of second order hyperbolic equations in non-divergence form, where the model problem includes a rapidly oscillating coefficient function. These small scales influence the large scale behavior, hence
Arjmand, Doghonay, Kreiss, Gunilla
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

The role of machine learning for insight into the material behavior of lattices: A surrogate model based on data from finite element simulation

Results in Engineering
In recent years, lattice structures have gained extensive attention due to their unique properties and great potential in various fields. Their effective material properties can be obtained by several means, e.g., numerical homogenization methods, finite
Pana Suttakul, Duy Vo, Thongchai Fongsamootr, Ramnarong Wanison, Yuttana Mona, Tossapon Katongtung, Nakorn Tippayawong, Itthidet Thawon   +7 more
doaj   +1 more source

Estimating effective conductivity of unidirectional transversely isotropic composites

Vietnam Journal of Mechanics, 2013
Three-point correlation bounds are constructed on effective conductivity of unidirectional composites, which are isotropic in the transverse plane.
Nguyen Trung Kien, Nguyen Van Luat, Pham Duc Chinh   +2 more
doaj   +1 more source

Homogenization of heterogeneous, fibre structured materials [PDF]

, 2013
This contribution presents a multi-scale homogenization method to model fibre structured materials. On the macroscopic level textiles are characterized by a large area-to-thickness ratio, such that a discretization with shell elements is numerically ...
Fillep, S., Mergheim, J., Steinmann, P.
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Identification in multiscale thermoelastic problems

Computer Assisted Methods in Engineering and Science, 2017
The paper deals with the identification in multiscale analysis of structures under thermal and mechanical loads. A two-scale model of porous materials is examined. Direct thermoelastic analyses with representative volume element (RVE) and finite element
Adam Długosz, Tadeusz Burczyński
doaj   +1 more source