Results 41 to 50 of about 1,215,494 (273)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Asymptotic Preserving time-discretization of optimal control problems for the Goldstein-Taylor model [PDF]

open access: yes, 2013
We consider the development of implicit-explicit time integration schemes for optimal control problems governed by the Goldstein-Taylor model. In the diffusive scaling this model is a hyperbolic approximation to the heat equation.
Albi, Giacomo   +3 more
core   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Bayesian Logistic Regression Model for Sub-Areas

open access: yesStats, 2023
Many population-based surveys have binary responses from a large number of individuals in each household within small areas. One example is the Nepal Living Standards Survey (NLSS II), in which health status binary data (good versus poor) for each ...
Lu Chen, Balgobin Nandram
doaj   +1 more source

Self-starting procedure simplifies numerical integration [PDF]

open access: yes, 1967
A self-starting, multistep procedure for the numerical integration of ordinary differential equations is devised to produce all the required backward differences directly from the initial equations.

core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Parameters Estimation in Non-Negative Integer-Valued Time Series: Approach Based on Probability Generating Functions

open access: yesAxioms, 2023
This manuscript deals with a parameter estimation of a non-negative integer-valued (NNIV) time series based on the so-called probability generating function (PGF) method.
Vladica Stojanović   +2 more
doaj   +1 more source

On the accuracy of the numerical integrals of the newmark’s method for computing inelastic seismic response [PDF]

open access: yes, 2019
The paper proposes an algorithm of the numerical integration with the modal analysis for computing inelastic seismic responses, and furthermore, the accuracy of the numerical integration with the Newmark’s =1/4 method that is most popular in the ...
Ijima, Katsushi   +3 more
core  

Parallelization of Runge–Kutta Methods for Hardware Implementation

open access: yesComputation, 2022
Parallel numerical integration is a valuable tool used in many applications requiring high-performance numerical solvers, which is of great interest nowadays due to the increasing difficulty and complexity in differential problems.
Petr Fedoseev   +4 more
doaj   +1 more source

Morphology of ledge patterns during step flow growth of metal surfaces vicinal to fcc(001) [PDF]

open access: yes, 2002
The morphological development of step edge patterns in the presence of meandering instability during step flow growth is studied by simulations and numerical integration of a continuum model.
C. Ghosh   +28 more
core   +2 more sources

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