Results 71 to 80 of about 144,309 (270)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
High-Precision Arithmetic in Mathematical Physics
Mathematics, 2015 For many scientific calculations, particularly those involving empirical data, IEEE 32-bit floating-point arithmetic produces results of sufficient accuracy, while for other applications IEEE 64-bit floating-point is more appropriate.
David H. Bailey, Jonathan M. Borwein
doaj +1 more source
Choosing integration points for QCD calculations by numerical integration [PDF]
, 2001 Davison E. Soper
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Evaluating statistical significance in a meta-analysis by using numerical integration. [PDF]
Comput Struct Biotechnol J, 2022 Lin YC, Liang YJ, Yang HC.
europepmc +1 more source
Error Bounds for the Numerical Integration of Functions with Limited Smoothness [PDF]
, 2014 Kai Diethelm
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Benchmarking of numerical integration methods for ODE models of biological systems. [PDF]
Sci Rep, 2021 Städter P +4 more
europepmc +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Error estimation for quadrature formulas based on equally spaced nodes
Mathematical Modelling and Analysis, 2006 The error estimation for quadrature formulas based on equally spaced nodes is discussed in this paper. The error estimates use embedded formulas and they are obtained for Newton‐Cotes and Hermitian quadrature formulas.
K. Plukas, D. Plukiene
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