Results 81 to 90 of about 1,215,494 (273)

Elastoplastic constitutive model considering the filling and cementation effects for gas hydrate-bearing sediments: development and finite element implementation

Frontiers in Earth Science
Dynamic evolution of hydrate filling and cementation effects significantly affects the mechanical behavior of gas hydrate-bearing sediments (GHBS).
Qingmeng Yuan, Qingmeng Yuan, Qingmeng Yuan, Qianyong Liang, Qianyong Liang, Jinqiang Liang, Jinqiang Liang, Zhigang Wang, Zhigang Wang, Lin Yang, Lin Yang, Xuemin Wu, Xuemin Wu, Binbin Guo, Binbin Guo, Yifei Dong, Yifei Dong   +16 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Errors in hybrid computers [PDF]

, 1972
Method is described for reduction of error components in numerical integration, sampling with zero hold order, and execution time ...
Alford, C. O., Hammond, J. L., Jr.
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Generalization of Companion of Ostrowski's Type Inequality Via Riemann-Liouville Fractional Integral and Applications in Numerical Integration, Probability Theory and Special Means [PDF]

Sahand Communications in Mathematical Analysis
We apply the Riemann-Liouville fractional integral to generalize a companion of Ostrowski's type integral inequality. The present article recaptures all the results of M. W.
Faraz Mehmood, Akhmadjon Soleev
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

CDR-Solv: Solving the Convection-Diffusion-Reaction Equation with Algebraic Sub-Grid Scale Stabilization Using Python

Applied Sciences
The convection-diffusion-reaction (CDR) equation is a fundamental mathematical model for simulating the transport of pollutants. It is a crucial tool for addressing global environmental challenges.
Ángel P. Villota-Cadena, Iván P. Sandoval-Palis, Gabriel F. Grijalva-Villegas, Erick P. Herrera-Granda   +3 more
doaj   +1 more source