Results 101 to 110 of about 1,215,494 (273)

Benchmarking of numerical integration methods for ODE models of biological systems. [PDF]

Sci Rep, 2021
Städter P, Schälte Y, Schmiester L, Hasenauer J, Stapor PL.   +4 more
europepmc   +1 more source

Computer program ETC improves computation of elastic transfer matrices of Legendre polynomials P/0/ and P/1/ [PDF]

, 1967
Computer program ETC improves computation of elastic transfer matrices of Legendre polynomials P/0/ and P/1/. Rather than carrying out a double integration numerically, one of the integrations is accomplished analytically and the numerical integration ...
Gibson, G., Miller, M.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Dynamical Model of Rotation and Orbital Coupling for Deimos

Remote Sensing
This paper introduces a novel dynamical model, building upon the existing dynamical model for Deimos in the current numerical ephemerides, which only encompasses the simple libration effects of Deimos.
Kai Huang, Lijun Zhang, Yongzhang Yang, Mao Ye, Yuqiang Li   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Research of efficiency of algorithms of method Everhart with high order of approximating formulas

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2012
The modified algorithm for the numerical integration of the equations of celestial motion by the Everharts method is developed. The study of the effectiveness of the algorithm for approximating high-order formulas is carried. High efficiency of the method
Artem A Zausaev
doaj  

Assessing the Metrological Reliability of Static Firing Tests of Rocket Motors Through the Evaluation of Thrust and Total Impulse Measurement Uncertainty

Applied Sciences
A solid propellant rocket motor is a propulsion system used in missiles and rockets that burns a propellant, typically composed of a mixture of fuel and an oxidizer, to generate the thrust necessary to propel the vehicle.
Fernando de Paula Leite Castor, Carlos Roberto Hall Barbosa, Elcio Cruz de Oliveira   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Numerical integration of celestial bodies equations with taking into account regularization and use osculating elements of major planets

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2010
The regular differential equations for a problem of perturbed motion are received. The computing algorithm and the program of numerical integration of the equations of celestial motion by a method of Everhart taking into account regularization and use ...
Dmitriy A Zausaev, Leonid A Solov'ev
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source