Results 111 to 120 of about 209,471 (303)

Dynamical Model of Rotation and Orbital Coupling for Deimos

Remote Sensing
This paper introduces a novel dynamical model, building upon the existing dynamical model for Deimos in the current numerical ephemerides, which only encompasses the simple libration effects of Deimos.
Kai Huang, Lijun Zhang, Yongzhang Yang, Mao Ye, Yuqiang Li   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Assessing the Metrological Reliability of Static Firing Tests of Rocket Motors Through the Evaluation of Thrust and Total Impulse Measurement Uncertainty

Applied Sciences
A solid propellant rocket motor is a propulsion system used in missiles and rockets that burns a propellant, typically composed of a mixture of fuel and an oxidizer, to generate the thrust necessary to propel the vehicle.
Fernando de Paula Leite Castor, Carlos Roberto Hall Barbosa, Elcio Cruz de Oliveira   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A numerical integration formula for the solution of the singular integral equation for classical crack problems in plane and antiplane elasticity

, 1991
Associate Professor, Dept. of Prod. Eng. & Mech. System Design, King Abdul aziz University, P. O. Box 9027, Jeddah 21413, Saudi Arabia and* Graduate Student, Dept.
Darned, Mostafa A., Cummins, Barry
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Numerical integration schemes for Petrov-Galerkin infinite BEM

, 2008
The present article discusses the numerical approximation of hypersingular integral equations arising from Neumann two-dimensional elliptic problems defined over unbounded domains with unbounded boundaries by using a Petrov-Galerkin infinite boundary ...
A. Aimi, M. Diligenti, DILIGENTI, Mauro, AIMI, Alessandra   +3 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A note on a family of quadrature formulas and some applications [PDF]

Opuscula Mathematica, 2008
In this paper a construction of a one-parameter family of quadrature formulas is presented. This family contains the classical quadrature formulas: trapezoidal rule, midpoint rule and two-point Gauss rule.
Bogusław Bożek, Wiesław Solak, Zbigniew Szydełko   +2 more
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source