Results 131 to 140 of about 209,471 (303)
Approximation of the Stieltjes Integral and Applications in Numerical Integration
, 2003 Some inequalities for the Stieltjes integral and applications in numerical integration are given. The Stieltjes integral is approximated by the product of the divided difference of the integrator and the Lebesgue integral of the integrand.
Cerone, Pietro, Dragomir, Sever S
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Recent Developments in Numerical Integration
, 1974 Classical and even modern developments of numerical integration have not been directly concerned with the frequency-response of integration algorithms.
J. M. Smith
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The boundary element method (BEM) has become a powerful method for the numerical solution of boundary-value problems (BVPs), due to its ability (at least ...
Al-Jawary, Majeed
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Lie–Butcher series and geometric numerical integration on manifolds [PDF]
, 2011 The thesis belongs to the field of “geometric numerical integration” (GNI), whose aim it is to construct and study numerical integration methods for differential equations that preserve some geometric structure of the underlying system. Many systems have
Lundervold, Alexander
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Survey on the Numerical Methods for ODE's Using the Sequence of Successive Approximations
, 2005 Here we present the error estimations in the numerical methods for Cauchy problems corresponding to ODE’s, which use the sequence of successive approximations and quadrature rules such as trapezoidal rule and perturbed trapezoidal ...
Bica, Alexandru Mihai
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source