Results 131 to 140 of about 4,993,210 (294)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Institute on Community Integration Annual Report: 2007-08
, 2008 The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Center for Excellence in Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Institute on Community Integration Annual Report: 1994-95
, 1995 The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Affiliated Program on Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Institute on Community Integration Annual Report: 1995-96
, 1996 The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Affiliated Program on Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Institute on Community Integration Annual Report: 2006-07
, 2007 The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Center for Excellence in Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Institute on Community Integration Annual Report: 2004-05
, 2005 The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Center for Excellence in Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core