Results 71 to 80 of about 5,204,168 (291)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Numerical analysis of structure preserving Nyström methods for Hamiltonian systems [PDF]
, 2005 Energy conservation is an essential property of conservative mechanical systems that should be carried over to the numerical solution. Betsch and Steinmann proposed recently perturbed potentials to achieve energy conservation in the time integration of N-
Pfeiffer, Andreas, Arnold, Martin
core
, 2012 Rectangles, Trapezoids, and Simpson's I just wrapped up a semester of calculus TA duties, and I thought it would be fun to revisit the problem of integration from a numerical standpoint.
openaire +2 more sources
Frontiers in Earth ScienceDynamic evolution of hydrate filling and cementation effects significantly affects the mechanical behavior of gas hydrate-bearing sediments (GHBS).
Qingmeng Yuan +16 more
doaj +1 more source
Driver’s influence on kinematics of articulated bus
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013 Driver’s influence on kinematics of articulated bus. This paper studies kinematics properties of the particle coach as function of driver’s activity. The main goals are the prediction of the trajectory, the computation of the vector of velocity of each ...
Tomáš Krumpholc, Stanislav Bartoň
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
A varying time-step explicit numerical integration algorithm for solving motion equation
, 2005 If a traditional explicit numerical integration algorithm is used to solve motion equation in the finite element simu- lation of wave motion, the time-step used by numerical integration is the smallest time-step restricted by the stabil- ity criterion in
尹晓涛 +4 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source