Results 51 to 60 of about 450,807 (339)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Hydration of a B-DNA Fragment in the Method of Atom-atom Correlation Functions with the Reference Interaction Site Model Approximation

, 1998
We propose an efficient numerical algorithm for solving integral equations of the theory of liquids in the Reference Interaction Site Model (RISM) approximation for infinitely dilute solution of macromolecules with a large number of atoms.
A. V. Gorelov, D. A. Tikhonov, E. G. Timoshenko, K. A. Dawson, Monson P. A., R. V. Polozov, Talitskih S. K., Teplukhin A. V., Tikhonov D. A., Yu. A. Kuznetsov, Zhurkin V. B.   +10 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Some considerations on numerical methods for Cauchy singular integral equations on the real line

Mathematical Modelling and Analysis
Two different direct methods are proposed to solve Cauchy singular integral equations on the real line. The aforementioned methods differ in order to be able to prove their convergence which depends on the smoothness of the known term function in the ...
Maria Rosaria Capobianco, Giuliana Criscuolo   +1 more
doaj   +1 more source

Finite-part singular integral approximations in Hilbert spaces

International Journal of Mathematics and Mathematical Sciences, 2004
Some new approximation methods are proposed for the numerical evaluation of the finite-part singular integral equations defined on Hilbert spaces when their singularity consists of a homeomorphism of the integration interval, which is a unit circle, on ...
E. G. Ladopoulos, G. Tsamasphyros, V. A. Zisis   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Accelerated Exponentially Fitted Operator Method for Singularly Perturbed Problems with Integral Boundary Condition

International Journal of Differential Equations, 2020
In this paper, we consider a class of singularly perturbed differential equations of convection diffusion type with integral boundary condition. An accelerated uniformly convergent numerical method is constructed via exponentially fitted operator method ...
Habtamu Garoma Debela, Gemechis File Duressa   +1 more
doaj   +1 more source

A Singularity-free Boundary Equation Method for Wave Scattering

, 2010
Traditional boundary integral methods suffer from the singularity of Green's kernels. The paper develops, for a model problem of 2D scattering as an illustrative example, singularity-free boundary difference equations.
Tsukerman, Igor
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source