Results 71 to 80 of about 87,253,677 (294)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Numerical Solution of Integral-Algebraic Equations with Weakly Singular Kernels by k−step Methods

Известия Иркутского государственного университета: Серия "Математика", 2015
In this paper we describe numerical methods for solution integral-algebraic equations wiht weakly singular kernels. Methods are based on explicit Adam’s methods, product integration methods for the integral part and on extrapolation formulas for the main
M.V. Bulatov, O.S. Budnikova
doaj  

A Hybrid Numerical Method Combining Legendre Polynomials and Improved Block-Pulse Functions for Solving Linear Systems of Fredholm Integral Equations

Axioms
In order to solve linear systems of Fredholm integral equations, this paper proposes a novel hybrid numerical method that combines improved block-pulse functions with Legendre polynomials.
Mohammed Z. Alqarni, Mohamed A. Ramadan, Heba S. Osheba   +2 more
doaj   +1 more source

Iterative Splitting Methods for Integrodifferential Equations: Theory and Applications

Journal of Applied Mathematics, 2014
We present novel iterative splitting methods to solve integrodifferential equations. Such integrodifferential equations are applied, for example, in scattering problems of plasma simulations.
Jürgen Geiser
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Approximation of solution of two-dimensional Volterra integral equation with a loaded operator

Известия высших учебных заведений. Поволжский регион: Физико-математические науки
Background. The research is devoted to the numerical solution of two-dimensional integral equations with an integral operator containing the trace of the unknown solution in the form of a linear combination of its values in a finite set of points.
Vladimir A. Ryazantsev, Aleksandr N. Tynda   +1 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Iterative methods for solving quadratic Volterra integral equations of the first kind

Известия высших учебных заведений. Поволжский регион: Физико-математические науки
Background. The paper is devoted to the numerical study of integral equations of the first kind with quadratic nonlinearity, which are part of the generalized Volterra integropower series and describe dynamical systems with one input and one output. Such
A.N. Tynda
doaj   +1 more source

The Modified Degenerate Kernel Method for the Multi-Dimensional Fredholm Integral Equations of the Second Kind

پژوهش‌های ریاضی, 2020
Introduction For the scientific study of a natural phenomenon it must be modeled. The resulting model is often expressed as a differential equation (DE), an integral equation (IE) or an integro-differential equation (IDE) or a system of these. Therefore,
Ahmad Molabahrami
doaj