Results 81 to 90 of about 87,253,677 (294)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

‎Multistep collocation method for nonlinear delay integral equations [PDF]

Sahand Communications in Mathematical Analysis, 2016
‎The main purpose of this paper is to study the numerical solution of nonlinear Volterra integral equations with constant delays, based on the multistep collocation method.
Parviz Darania
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Solving optimal control problems with integral equations or integral equations - differential with the help of cubic B-spline scaling functions and wavelets

پژوهش‌های ریاضی, 2020
Introduction Optimal control problems (OCPs) appear in a wide class of applications. In the classical control problems, the state-space equations are expressed as differential equations.
Hamid Mesgarani, Hamid Safdari, Abolfazl Ghasemian   +2 more
doaj  

Numerical Contour Integral Methods for Free-Boundary Partial Differential Equations Arising in American Volatility Options Pricing

Discrete Dynamics in Nature and Society, 2018
The aim of this paper is to study the numerical contour integral methods (NCIMs) for solving free-boundary partial differential equations (PDEs) from American volatility options pricing. Firstly, the governing free-boundary PDEs are modified as a unified
Yong Chen, Jianjun Ma
doaj   +1 more source

Supplementing the numerical solution of singular/hypersingular integral equations/inequalities with parametric inequality constraints with applications to crack problems

Computer Assisted Methods in Engineering and Science, 2017
Singular and hypersingular integral equations appear frequently in engineering problems. The approximate solution of these equations by using various numerical methods is well known.
Nikolaos I. Ioakimidis
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Comparison between variational iteration method and Gegenbauer–Galerkin method for solving two dimensional nonlinear Volterra integral equations of the second kind [PDF]

AIP Advances
This paper intends to introduce two numerical techniques—the variational iteration method and the Gegenbauer–Galerkin method—for obtaining solutions to two dimensional nonlinear Volterra integral equations of the second kind.
M. H. Ahmed
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Higher order parallel splitting methods for parabolic partial differential equations [PDF]

, 1995
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The thesis develops two families of numerical methods, based upon new rational approximations to the matrix exponential function, for solving second-order ...
Taj, Malik Shahadat Ali
core   +4 more sources