Results 141 to 150 of about 6,208 (302)

Realtime Simulation of Detailed Vehicle and Powertrain Dynamics

, 2004
This paper describes typical modeling and real-time simulation issues that occur in automotive applications. Real-time simulations of detailed Modelica benchmark models for chassis and powertrain are presented.
Johan Andreasson, Andreasson, Johan, Otter, Martin, Mattsson, Sven Erik, Christian Schweiger, Dag Brück, Brück, Dag, Hans Olsson, Sven Erik Mattsson, Hilding Elmqvist, Elmqvist, Hilding, Martin Otter, Olsson, Hans, Schweiger, Christian   +13 more
core   +1 more source

SageNet: Fast Neural Network Emulation of the Stiff-amplified Gravitational Waves from Inflation

The Astrophysical Journal Supplement Series
Accurate modeling of the inflationary gravitational waves (GWs) requires time-consuming, iterative numerical integrations of differential equations to take into account their backreaction on the expansion history.
Fan Zhang, Yifang Luo, Bohua Li, Ruihan Cao, Wenjin Peng, Joel Meyers, Paul R. Shapiro   +6 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Partitioned Adaptive Parallel Integrators for Coupled Stiff Systems

, 2019
The efficient numerical simulation of stiff multiphysics systems remains a core challenge in scientific computing. Examples are fluid structure interaction, earth system models or turbulent flames. We consider problems with the following characteristics:
Birken, Philipp
core  

Stabilized multilevel Monte Carlo method for stiff stochastic differential equations [PDF]

A multilevel Monte Carlo (MLMC) method for mean square stable stochastic differential equations with multiple scales is proposed. For such problems, that we call stiff, the performance of MLMC methods based on classical explicit methods deteriorates ...
Blumenthal, Adrian, Abdulle, Assyr
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The numerical solution of boundary value problems for stiff differential equations

, 1977
The numerical solution of boundary value problems for certain stiff ordinary differential equations is studied. The methods developed use singular perturbation theory to construct approximate numerical solutions which are valid asymptotically; hence ...
R. E. O’Malley, Joseph E. Flaherty
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Structure preserving spectral methods and exponential integrators for the numerical solution of stiff semi-linear partial differential equations

, 2020
In this thesis, we present numerical solution of semilinear partial differential equations (PDEs) where the linear differential operator is a self-adjoint.
Appiah-Kubi, Emmanuel
core