Results 131 to 140 of about 6,208 (302)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Modeling dynamic and static operating modes of a low-power asynchronous electric drive

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
The article presents a mathematical model of the asynchronous motor in oblique coordinates, based on differential equations expressed in the standard Cauchy form.
Viktor Lyshuk, Sergiy Moroz, Yosyp Selepyna, Valentyn Zablotskyi, Mykola Yevsiuk, Viktor Satsyk, Anatolii Tkachuk   +6 more
doaj   +1 more source

Numerical stability of the multi-step methods to solve the stiff equation by using the CADNA library

, 2016
In this paper, based on the stochastic arithmetic, the accuracy and stability of multi-step methods to solve the stiff differential equation is studied. By using the CESTAC method and the CADNA library, the optimal iterate and the optimal step size of the multi-step methods can be dynamically computed and its accuracy can be estimated.
Hasan Barzegar, MohammadAli Fariborzi Araghi   +1 more
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Two-step hybrid numerical integrators for the solutions of highly oscillatory systems of ODEs with fixed step size

Scientific African
Collocation methods have shown great promise in developing numerical techniques for solving stiff and highly oscillatory problems in ordinary differential equations.
Dauda G. Yakubu, Joshau P. Chollom, Adelegan L. Momoh, Geoffrey M. Kumleng   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Improved Rosenbrock method with error estimator and Jacobian approximation using complex step

Results in Applied Mathematics
This paper proposes an A-stable one-stage Rosenbrock method for the solution of Ordinary Differential Equations (ODEs). In this method, Jacobians are approximated via complex step finite differences. An asymptotically accurate estimator of the truncation
Juan Diego Pulgarín Rivera, Daniel Turizo, Elias D. Nino-Ruiz, Oscar Danilo Montoya   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Adaptive finite elements for viscoelastic deformation problems

, 2008
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis is concerned with the theoretical and computational aspects of generating solutions to problems involving materials with fading memory, known as
Hill, Harry
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