Results 121 to 130 of about 891,924 (295)

Distribution and trend of explosive cyclones over the Southern Ocean and associated atmospheric and oceanic changes during 1980–2020

Geoscience Letters
In this study, we investigate the climatology and trend of explosive cyclones (ECs) over the Southern Ocean (50oS–70oS) during 1980–2020 by combining a method that is most suited for identifying and tracking cyclones in the Southern Ocean and a latest ...
Xiaoqi Xu, Jiping Liu, Gang Huang, Yifan Ding   +3 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Interannual connection of winter Barents-Kara sea-ice variability to ENSO regulated by Atlantic Multidecadal Oscillation

Environmental Research Communications
In this study, the impact of Atlantic Multidecadal Oscillation (AMO) on the connection of winter sea-ice concentration (SIC) over Barents-Kara Seas (BKS) to El Niño-Southern Oscillation (ENSO) is explored.
Jiaqi Shi, Binhe Luo, Yao Yao, Dehai Luo
doaj   +1 more source

Biased Aerosol Wet Deposition CAM5 Simulations: A Result of Misrepresented Convective-Stratiform Precipitation Partitioning When Benchmarked Against SPCAM

Remote Sensing
Wet deposition is a major sink for atmospheric aerosols, but its representation in conventional global climate models (GCMs) remains highly uncertain, partly as a result of the partitioning between convective and stratiform precipitation. Using the Super-
Wenwen Xia, Yujun He, Bin Wang
doaj   +1 more source

A novel technique for modelling interfaces in reinforced brittle materials [PDF]

, 2001
A novel numerical technique for the modelling of interfaces is introduced for the analysis of reinforced brittle materials. The method exploits the partition of unity property of finite element shape functions.
Simone, A, Sluys, LJ, Wells, GN
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Development and Evaluation of Neural Network Architectures for Model Predictive Control of Building Thermal Systems

Buildings
The operational and indoor environmental quality of buildings has a significant impact on global energy consumption and human quality of life. One of the key directions for improving building performance is the optimization of building control systems ...
Jevgenijs Telicko, Andris Krumins, Agris Nikitenko   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Influence of SST‐Precipitation Relationship Over the Equatorial Western Pacific on Simulation of the Madden‐Julian Oscillation

Geophysical Research Letters
Capabilities of 43 models of the Coupled Model Intercomparison Project Phase 6 (CMIP6) to simulate the Madden‐Julian Oscillation (MJO) were compared in this study.
Guiwan Chen, Jian Ling, Ziniu Xiao, Chongyin Li, Chidong Zhang   +4 more
doaj   +1 more source