Results 81 to 90 of about 7,929,866 (305)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

A new continuous optimization method of standardized cubic permanent magnets for stellarators

Nuclear Fusion
Stellarator configurations can be realized using permanent magnets in combination with tokamak-like planar coils. From the perspective of engineering feasibility and cost-effectiveness, using standardized cubic permanent magnets with a finite number of ...
Xiangyu Zhang, Dehong Chen, Guosheng Xu, Zhiyuan Lu, Caoxiang Zhu, Liang Chen, Minyou Ye, Baonian Wan   +7 more
doaj   +1 more source

Handling Multiple Scenarios in Evolutionary Multiobjective Numerical Optimization

IEEE Transactions on Evolutionary Computation, 2018
Solutions to most practical numerical optimization problems must be evaluated for their performance over a number of different loading or operating conditions, which we refer here as scenarios.
K. Deb, Ling Zhu, S. Kulkarni
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Enhancing C2 and C3 coherency resolutions through optimizing semblance-based functions [PDF]

Geofísica Internacional, 2007
Apparent dips from 3-D reflectors are calculated by maximizing the semblance-based coherency (C2) by numerical optimization techniques. This maximization was done by means of searching through a tessellation of the apparent dips domain, and by ...
J.O. Campos-Enriquez, F. Reyes-Ramos
doaj  

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Self-supporting structure design in additive manufacturing through explicit topology optimization

, 2017
One of the challenging issues in additive manufacturing (AM) oriented topology optimization is how to design structures that are self-supportive in a manufacture process without introducing additional supporting materials. In the present contribution, it
Du, Zongliang, Guo, Xu, Liu, Chang, Liu, Ying, Zhang, Weisheng, Zhou, Jianhua   +5 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Application of Exact Newton Optimisation to the Maximum Likelihood Ensemble Filter

Tellus: Series A, Dynamic Meteorology and Oceanography
The Newton method is used for optimisation in the maximum likelihood ensemble filter (MLEF) to improve analysis convergence and accuracy. The proposed method is compared against the original method using the conjugate gradient (CG) method preconditioned ...
Takeshi Enomoto, Saori Nakashita
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source