Results 81 to 90 of about 922,998 (286)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Multidimensional optimization algorithms numerical results [PDF]
This paper presents some multidimensional optimization algorithms. By using the "penalty function" method, these algorithms are used to solving an entire class of economic optimization problems.
Iulian MIRCEA +2 more
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Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Optimization of Water Based Drilling Fluid Produced Using Modified Nigerian Bentonite and Natural Biopolymers: Reduced experiment and Response Surface Methodology [PDF]
Iranian Journal of Chemical Engineering, 2019 Research has shown that many Bentonite in Nigeria are unsuitable for oil well drilling in their natural states. Their modification and blends with some additives could increase the yield and boost their suitability.
A. Arinkoola +5 more
doaj
Aerodynamic design using numerical optimization [PDF]
The procedure of using numerical optimization methods coupled with computational fluid dynamic (CFD) codes for the development of an aerodynamic design is examined.
Chapman, G. T., Murman, E. M.
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Factorisable Multitask Quantile Regression
, 2020 A multivariate quantile regression model with a factor structure is proposed to study data with many responses of interest. The factor structure is allowed to vary with the quantile levels, which makes our framework more flexible than the classical ...
Chao, Shih-Kang +2 more
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
A note on evolutionary stochastic portfolio optimization and probabilistic constraints [PDF]
, 2010 In this note, we extend an evolutionary stochastic portfolio optimization framework to include probabilistic constraints. Both the stochastic programming-based modeling environment as well as the evolutionary optimization environment are ideally suited ...
Hochreiter, Ronald
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