Results 261 to 270 of about 2,810,960 (342)

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

The impact of nurses' perfectionistic self-presentation and toxic leadership of nurse managers on workplace incivility: a cross-sectional study. [PDF]

BMC Nurs
Oh YH, Son YJ, Jang SJ, Lee H.
europepmc   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Functions and Activities Missed by Nurse Managers, Their Antecedents and Consequences: Findings From a Qualitative Study. [PDF]

J Nurs Manag
Chiappinotto S, Eskici GT, Miorin F, Palese A.   +3 more
europepmc   +1 more source

Navigating Role Transition: A Qualitative Study of How New Nurse Managers Develop Resilient Leadership. [PDF]

J Nurs Manag
Song Z, Wang J, Gao P, Xu X, Huang X.
europepmc   +1 more source

Leadership Experiences of Nurse Managers in a Saudi Ministry of Health Hospital: A Focused Ethnographic Study. [PDF]

J Nurs Manag
Alenezi IN.
europepmc   +1 more source

Acceptance of Electronic Medical Records Among Practitioner Nurses and Nurse Managers Using the UTAUT Framework in Hospital Settings: A Scoping Review. [PDF]

J Multidiscip Healthc
Liana Y, Agustina HR, Yudianto K.
europepmc   +1 more source

A Cross-Sectional Study of Clinical Leadership Needs and Safety Climate: Differences Between Nurses and Nurse Managers. [PDF]

SAGE Open Nurs
Mrayyan MT, Ismail JMA.
europepmc   +1 more source

The relationship between leadership styles of nurse managers, nurse motivation, and turnover intention among nurses in Saudi Arabia: A descriptive correlational study. [PDF]

Belitung Nurs J
Aldhafeeri NA, Alshutwi SS, Alotaibi AM, Alanaza AE, Jaber AH, Alharbi AS, Alowais RK.   +6 more
europepmc   +1 more source