Results 111 to 120 of about 3,987,320 (352)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Regulation of soil properties by amendments and their impact on Cd fractions and bacterial community structure: Exploring the mechanism of inhibition on Cd phytoavailability

Ecotoxicology and Environmental Safety
The application of soil amendments is crucial for mitigating cadmium (Cd) phytoavailability in Cd-contaminated paddy fields, thereby promoting safer rice production.
Linfeng Li, Qi Li, Anwen Xiao, Chonghua Li, YiChun Li   +4 more
doaj   +1 more source

Nutrient cycling in mango trees

Semina: Ciências Agrárias, 2014
Estimates of nutrient amounts both shedding and demanding replacement in the maintenance of productivity of fruit trees require studies on element dynamics within the many ecosystem components generally made up of nutrient cycling.
Cinara Xavier de Almeida , José Luiz Pita Junior , Danilo Eduardo Rozane , Henrique Antunes de Souza , Amanda Hernandes , William Natale, Antonio Sergio Ferraudo   +6 more
doaj   +1 more source

Data for life cycle assessment of legume biorefining for alcohol [PDF]

, 2019
Benchmarking the environmental sustainability of alcohol produced from legume starch against alcohol produced from cereal grains requires considering of crop production, nutrient cycling and use of protein-rich co-products via life cycle assessment. This
Black, Kirsty, Chadwick, David, Iannetta, Pietro, Leinhardt, Theophile, Porto Costa, Marcela, Rees, Robert M., Saget, Sophie, Spillane, Charles, Styles, David, Walker, Graeme, Williams, Michael   +10 more
core   +4 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Integrated Soil–Crop System Management Promotes Sustainability of Intensive Vegetable Production in Plastic Shed Systems: A Case Study in the Yangtze River Basin, China

Agronomy
Excessive fertilizer input, low nutrient use efficiency, soil quality, and environmental degradation hinder greenhouse vegetable production. Integrated agronomic strategies of soil, crop, and nutrient management are needed to sharply improve the ...
Gang Wu, Bin Liu, Mingjiong Zhao, Long Liu, Sujun Wei, Manman Yuan, Jiabao Wang, Xinping Chen, Xiaozhong Wang, Yixiang Sun   +9 more
doaj   +1 more source

The impact of soil and vegetation management on ecosystem services in european almond orchards [PDF]

, 2018
N/
Leijster, V.
core  

Trees enhance soil carbon sequestration and nutrient cycling in a silvopastoral system in south-western Nicaragua

Agroforestry Systems, 2016
Tree occurrence in silvopastoral systems of Central America has been under pressure for various reasons including attempts to improve grassland productivity and the need for wood. However, scattered isolated trees are also recognized to provide ecosystem
M. Hoosbeek, R. Remme, G. Rusch
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source