Results 81 to 90 of about 297,571 (276)

Interactive effects of dietary energy levels with amino acid density on growth performance and optimal digestible Lys to energy ratio of male broiler chickens

open access: yesPoultry Science
: A total of 2,400 day-old off-sex male Ross 308 chicks were used in a 4 × 3 factorial array (8 replicates with 25 birds per replicate) to determine the interactive effects of dietary metabolizable energy (ME) and amino acid (AA) densities on productive ...
Mehdi Toghyani   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Nutrient-sensitive approach for sustainability assessment of different dietary patterns in Australia

open access: yes, 2022
Background: Understanding the relation between sustainability and nutrients is important in devising healthy and sustainable diets. However, there are no prevailing methodologies to assess sustainability at the nutrient level.
D Raubenheimer (13329537)   +5 more
core  

Energy intake and dietary patterns in childhood and throughout adulthood and mammographic density: results from a British prospective cohort. [PDF]

open access: yes, 2010
OBJECTIVES: To examine the role of energy intake and dietary patterns in childhood and throughout adulthood on subsequent mammographic density. METHODS: Prospective data were available from a cohort of 1161 British women followed up since their birth in ...
Isabel dos Santos Silva   +17 more
core   +1 more source

An Alarming Decline in the Nutritional Quality of Foods: The Biggest Challenge for Future Generations’ Health

open access: yesFoods
In the last sixty years, there has been an alarming decline in food quality and a decrease in a wide variety of nutritionally essential minerals and nutraceutical compounds in imperative fruits, vegetables, and food crops. The potential causes behind the
Raju Lal Bhardwaj   +3 more
doaj   +1 more source

Comparison of Nutrient Density and Nutrient-to-Cost Between Cooked and Canned Beans

open access: yesFood and Nutrition Sciences, 2011
Consumption of nutrient rich foods such as beans and peas is recommended because these foods provide key nutrients and relatively little energy. Many consumers are unfamiliar with dried beans or do not have the time to prepare them. The purpose of this study was to compare nutrient density and nutrient-to-cost among dried cooked, canned (liquid and ...
Michael Zanovec   +2 more
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Role of Dietary Saccharomyces boulardii in Innate Immune Responses of Broiler Chickens Fed Diets Containing Different Nutrient Densities

open access: yesAnimals
The study was conducted to evaluate the influence of Saccharomyces boulardii (SB) supplementation on growth performance, meat quality, cecal volatile fatty acid (VFA) profile, immune parameters, and serum biochemistry in broiler chickens fed diets with ...
Viet Anh Vu   +4 more
doaj   +1 more source

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