Results 161 to 170 of about 271,445 (306)

Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid

open access: yesAdvanced Functional Materials, EarlyView.
In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang   +16 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

open access: yesAdvanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth   +2 more
wiley   +1 more source

Global environmental and nutritional assessment of national food supply patterns: Insights from a data envelopment analysis approach

open access: hybrid, 2020
Elysia Lucas   +4 more
openalex   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

open access: yesAdvanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram   +5 more
wiley   +1 more source

Bio‐Responsive Hydrogel for Targeted on‐Demand Release of a Phage Cocktail for Treatment of Pseudomonas aeruginosa Infection

open access: yesAdvanced Functional Materials, EarlyView.
This study presents an injectable hydrogel that responds to Pseudomonas aeruginosa infection by releasing a dual‐phage cocktail on demand. The system degrades selectively in infected wounds, enhances phage localization and stability, and shows potent antibiofilm activity and biocompatibility in an ex vivo human skin model—offering a promising strategy ...
Siyuan Tao   +9 more
wiley   +1 more source

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