Results 81 to 90 of about 5,533,518 (394)
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
A survey on AI nutrition recommender systems [PDF]
Proceedings of the 12th ACM International Conference on PErvasive Technologies Related to Assistive Environments, 2019 The goal of this work is to provide an overview of existing approaches regarding AI nutrition recommender systems. A breakdown of such systems into task-specific components is presented, as well as methodologies concerned with each individual component.
Theodoridis, Thomas +4 more
openaire +1 more source
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Machine learning-based prediction of vitamin D deficiency: NHANES 2001-2018
Frontiers in EndocrinologyBackgroundVitamin D deficiency is strongly associated with the development of several diseases. In the current context of a global pandemic of vitamin D deficiency, it is critical to identify people at high risk of vitamin D deficiency.
Jiale Guo, Qionghan He, Yehai Li
doaj +1 more source
A holistic approach to enhance the use of neglected and underutilized species: the case of Andean grains in Bolivia and Peru [PDF]
, 2014 The IFAD-NUS project, implemented over the course of a decade in two phases, represents the first UN-supported global effort on neglected and underutilized species (NUS).
Amaya, K. +5 more
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Emerging Themes in Epidemiology, 2007 In this paper we explore the strengths and gaps among NGO surveys based on an analysis of the records held in the CE-DAT database at CRED. We conclude by recommending the priority areas for strengthening NGO capacity to undertake surveys and ways to ...
Olivier Degomme, D. Guha-Sapir
semanticscholar +1 more source
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Does geographic targeting of nutrition interventions make sense in cities? [PDF]
Although most developing country cities are characterized by pockets of substandard housing and inadequate service provision, it is not known to what degree low incomes and malnutrition are confined to specific neighborhoods.
Armar-Klemesu, Margaret +4 more
core
Medical Examination in Nutrition Surveys [PDF]
The Journal of Nutrition, 2005 Pellagra was the most important deficiency disease used as a model for nutrition surveys, because its diagnosis depended on physical signs. By the mid twentieth century, laboratory tests improved the specificity of physical signs in diagnosis of deficiency disease. The author uses his experience in Panama to illustrate how attention to the details of a
openaire +3 more sources
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source