Results 71 to 80 of about 455,995 (316)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Nutritional Management for Chronic Liver Disease—Current Trends and Future Prospects [PDF]

It has been well established that numerous nutritional factors, including macronutrients and micronutrients, are involved in the pathophysiology of chronic liver diseases [...
Takashi Himoto
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Assessing the nutritional value, fermentation quality, and in vitro degradability of mulberry pomace silage ensiled with sumac additive

Revista Científica
This study investigates the effects of sumac addition on the nutrient composition, in vitro degradability, and fermentation quality of mulberry pomace silage.
Pınar Tatlı Seven, Miray Sıla Çiçek, Seda İflazoğlu Mutlu, Furkan Melih Dadan, Numan Yusuf Aktaş   +4 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Effects of wheat, rye, and triticale grains on digestion, fecal quality, and health parameters in dogs

BMC Veterinary Research
Background There is a continuous search for healthy food ingredients for dog diets that do not compete with human consumption. Grains, which have been recently claimed to be unsuitable for dogs, are regaining interest.
Zekeriya Safa İnanç, Oğuzhan Kahraman, Mustafa Selçuk Alataş, Ibrar Ahmed, Mustafa Uludağ, Fatma İnal   +5 more
doaj   +1 more source

SOME HEMATOLOGICAL AND BLOOD SERUM BIOCHEMICAL INDICES ASSOCIATED WITH RESPIRATORY AFFECTIONS IN CAMELS

Assiut Veterinary Medical Journal, 2009
This study was carried out on 40 camels in Assuite governorate, 10 of them apparently healthy, 20, suffering from moderate respiratory signs and 10 cases suffering from severe respiratory signs.
EMAN M.A. EL-NASER, G.F.A. KHAMIS
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The nutritional transition and diet-related chronic diseases in Asia [PDF]

The nutritional transition currently occurring in Asia is one facet of a more general demographic/nutritional/epidemiological transition that accompanies development and urbanization, marked by a shift away from relatively monotonous diets of varying ...
Horton, Susan, Kim, Soowon, Popkin, Barry M.   +2 more
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