Results 21 to 30 of about 44,765 (253)

Development and validation of next generation sequencing based 35-gene hereditary cancer panel

Hereditary Cancer in Clinical Practice, 2020
Background Understanding the genetic basis of cancer risk is a major international endeavor. The emergence of next-generation sequencing (NGS) in late 2000’s has further accelerated the discovery of many cancer susceptibility genes.
Wing Chan, Mianne Lee, Zhen Xuan Yeo, Dingge Ying, Keith A. Grimaldi, Craig Pickering, Michael M. S. Yang, Senthil K. Sundaram, Lawrence C. H. Tzang   +8 more
doaj   +1 more source

miRNAs modified by dietary lipids in Caco-2 cells. A microarray screening

Genomics Data, 2015
We performed a screening of miRNAs regulated by dietary lipids in a cellular model of enterocytes, Caco-2 cells. Our aim was to describe new lipid-modified miRNAs with an implication in lipid homeostasis and cardiovascular disease [1,2]. For that purpose,
Lidia Daimiel, Jose Mª. Ordovás, Alberto Dávalos   +2 more
doaj   +1 more source

Position of the Academy of Nutrition and Dietetics: Nutritional Genomics [PDF]

Journal of the Academy of Nutrition and Dietetics, 2014
It is the position of the Academy of Nutrition and Dietetics that nutritional genomics provides insight into how diet and genotype interactions affect phenotype. The practical application of nutritional genomics for complex chronic disease is an emerging science and the use of nutrigenetic testing to provide dietary advice is not ready for routine ...
Kathryn M, Camp, Elaine, Trujillo
openaire   +2 more sources

Genome Editing for Improving Crop Nutrition [PDF]

Frontiers in Genome Editing, 2022
Genome editing technologies, including CRISPR/Cas9 and TALEN, are excellent genetic modification techniques and are being proven to be powerful tools not only in the field of basic science but also in the field of crop breeding. Recently, two genome-edited crops targeted for nutritional improvement, high GABA tomatoes and high oleic acid soybeans, have
Ai Nagamine, Hiroshi Ezura, Hiroshi Ezura   +2 more
openaire   +3 more sources

Short-Term Supplementation with 100% Bilberry Products and Its Effects on Body Composition and Lipid Profile in Overweight/Obese Women

Metabolites
Introduction: Overweight and obesity are major public health concerns, often leading to increased cardiovascular risk. Methods: This eight-week interventional study examined whether regular consumption of two natural bilberry products could improve body ...
Marta Habanova, Maros Bihari, Radek Latal, Martina Gažarova, Petra Lenártová, Jana Pastrnakova, Jadwiga Hamulka   +6 more
doaj   +1 more source

A qPCR-based assay to quantify oxidized guanine and other FPG-sensitive base lesions within telomeric DNA

BioTechniques, 2011
Telomere shortening is an important risk factor for cancer and accelerated aging. However, it is becoming evident that oxidatively damaged DNA within the telomere sequence may also cause telomere dysfunction.
Nathan O'Callaghan, Natalie Baack, Razinah Sharif, Michael Fenech   +3 more
doaj   +1 more source

Marigold Supercritical Extract as Potential Co-adjuvant in Pancreatic Cancer: The Energetic Catastrophe Induced via BMP8B Ends Up With Autophagy-Induced Cell Death

Frontiers in Bioengineering and Biotechnology, 2020
The recent development of powerful “omics” technologies (genomics, transcriptomics, proteomics, metabolomics, and lipidomics) has opened new avenues in nutritional sciences toward precision nutrition, which is a genotype-directed nutrition that takes ...
Marta Gómez de Cedrón, Lamia Mouhid, Elena García-Carrascosa, Tiziana Fornari, Guillermo Reglero, Guillermo Reglero, Ana Ramírez de Molina   +6 more
doaj   +1 more source

Patient-Derived Transcriptomics Reveals Distinct IFNγ-Associated Myeloid States and Mitochondrial Complex I Programs in Rheumatoid Arthritis and Osteoarthritis

Biomedicines
Background/Objectives: Macrophages are key contributors to the pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA), but their disease-associated immunometabolic states remain incompletely understood. Methods: Here, we comparatively analyzed
Heekyong R. Bae, Byeongchan Son, Seong-Su Choi, Hye-Bin Jeong, Howard A. Young, Eun-Young Kwon   +5 more
doaj   +1 more source

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis

Nature Communications, 2020
In response to insulin, liver cells increase de novo lipogenesis via the transcription factors USF-1 and SREBP. Here the authors show that USF-1 recruits JMJD1C, after its phosphorylation by mTOR, to lipogenic promoters where JMJD1C demethylates histone ...
Jose A. Viscarra, Yuhui Wang, Hai P. Nguyen, Yoon Gi Choi, Hei Sook Sul   +4 more
doaj   +1 more source

Current insights into genome-based personalized nutrition technology: a patent review

Frontiers in Nutrition
Unlike general nutritional ranges that meet the nutritional needs essential for maintaining the life of an entire population, personalized nutrition is characterised by maintaining health through providing customized nutrition according to individuals ...
Soo-Hyun Park, Hyo-Kyoung Choi, Jae Ho Park, Jin-Taek Hwang   +3 more
doaj   +1 more source