Results 71 to 80 of about 44,765 (253)

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Cytotoxic CD4⁺ T cells exhibit an immunosuppressive shift in checkpoint immunotherapy resistance in melanoma patients

Cancer Immunology, Immunotherapy
Although checkpoint immunotherapy has primarily focused on CD8⁺ T cells, emerging evidence highlights an important role for cytotoxic CD4⁺ T cells in mediating therapeutic responses.
Heekyong R. Bae, Byeongchan Son, Kyoungho Hwang, Suntae Kim, Howard A. Young, Eun-Young Kwon   +5 more
doaj   +1 more source

The Plant Genome special section: Grain quality and nutritional genomics for breeding next-generation crops. [PDF]

Plant Genome, 2023
Pandey MK, Mir RR, Sreenivasulu N.
europepmc   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Nutrigenomics and Nutrigenetics [PDF]

Iranian Journal of Public Health, 2010
The nutrients are able to interact with molecular mechanisms and modulate the physiological functions in the body. The Nutri­tional Genomics focuses on the interaction between bioactive food components and the genome, which includes Nutrigenet­ics and ...
DD Farhud , M Zarif Yeganeh, M Zarif Yeganeh   +2 more
doaj   +1 more source

A comprehensive review of oil biosynthesis pathways and integrated breeding interventions in sesame for nutritional enhancement

Journal of Plant Interactions
Sesame (Sesamum indicum L.) is an important oilseed crop valued for its high oil content and beneficial unsaturated fatty acids. However, low yield, susceptibility to biotic and abiotic stresses, and capsule shattering during mechanized harvesting limit ...
Waqas Mushtaq, Muhammad Munem Khan, Azizullah Khalili, Mehmood Ali Noor, Sajid Fiaz, Ibtisam Alatawi, Malaika Zaheer, Muhammad Talha Aslam, Saira Ghafoor, Muhammad Umair Hassan, Mvuyeni Nyasulu, Ziming Wu   +11 more
doaj   +1 more source

New insights into the nutritional genomics of adult-onset riboflavin-responsive diseases. [PDF]

Nutr Metab (Lond), 2023
Murgia C, Dehlia A, Guthridge MA.
europepmc   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

A review of the Mediterranean diet and nutritional genomics in relation to cancer in women. [PDF]

J Prev Med Hyg, 2022
Tuncel G, Hoti Q, Mocan G, Ergoren MC.
europepmc   +1 more source