Results 111 to 120 of about 695,674 (240)
AlphaFold‐Guided Bespoke Gene Editing Enhances Field‐Grown Soybean Oil Contents
Advanced Science, EarlyView.An AlphaFold‐guided method is developed to functionally optimize soybean sugar transporters and achieve bespoke gene editing of GmSWEET10a/b to improve oil content in an elite soybean cultivar in multi‐year, multi‐site field trials. The combination of AI‐guided protein design and gene editing may unlock a huge potential to improve the genetic trait de ...
Jie Wang +22 more
wiley +1 more source
Advanced Science, EarlyView.In the tripartite‐species model, Drosophila larvae stimulate lactate production through excreting digestion enzymes. S. marcescens population senses a cue of lactate and tends to diverge into virulent and reduced virulence subclusters with remarkable heterogeneity to metabolize carbon metabolism and counter colonization resistance, giving a fitness ...
Sheng Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.BMSCmotif+miR874/MS system is designed as a gene delivery platform utilizing engineered bone marrow mesenchymal stem cell (BMSC)‐derived extracellular vesicles (EVs) for intercellular communication to achieve sustained delivery of miRNA‐874‐3p. Rejuvenation of chondrocytes and promotion of chondrogenesis are achieved by inhibition of the NF‐κB pathway,
Yuezhou Wu +7 more
wiley +1 more source
Sports Medicine: Nutritional Sciences and Nutritional Biochemistry, Focusing on Nutritional Supplements from the FFNFO Framework to Contamination. [PDF]
Life (Basel)Bonilla DA +3 more
europepmc +1 more source
Joanne Curran-Celentano, Professor of Animal and Nutritional Sciences [PDF]
, 2010 Lee, Jennifer
core +1 more source
Identification and Application of a Novel Patulin Degrading Enzyme From Meyerozyma guilliermondii
Advanced Science, EarlyView.Patulin (PAT), a hazardous mycotoxin, threatens human health. A novel yeast‐derived short‐chain dehydrogenase/reductase effectively degrades PAT into nontoxic ascladiol via catalytic triad activity. The biological detoxification process has no significant effect on the quality of fresh pear juice.
Yu Zhang +7 more
wiley +1 more source
Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System
Advanced Science, EarlyView.This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao +7 more
wiley +1 more source
Advanced Science, EarlyView.Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang +8 more
wiley +1 more source