Results 51 to 60 of about 5,804,266 (292)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies.

Molecular Nutrition & Food Research, 2018
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing.
M. Ulaszewska, C. Weinert, A. Trimigno, R. Portmann, C. Andrés-Lacueva, R. Badertscher, L. Brennan, C. Brunius, A. Bub, F. Capozzi, Marta Cialiè Rosso, C. Cordero, H. Daniel, S. Durand, B. Egert, P. Ferrario, E. Feskens, P. Franceschi, M. Garcia-Aloy, F. Giacomoni, P. Giesbertz, R. González-Domínguez, K. Hanhineva, L. Hemeryck, J. Kopka, S. Kulling, R. Llorach, C. Manach, F. Mattivi, C. Migné, Linda H. Münger, B. Ott, G. Picone, Grégory Pimentel, E. Pujos-Guillot, S. Riccadonna, M. Rist, C. Rombouts, Josep Rubert, T. Skurk, Pedapati S. C. Sri Harsha, L. Van Meulebroek, L. Vanhaecke, R. Vázquez-Fresno, D. Wishart, G. Vergères   +45 more
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Promotion of Egg and Eggshell Powder Consumption on the Nutritional Status of Young Children in Ethiopia

International journal of food sciences and nutrition research, 2019
1 School of Nutrition, Food Science and Technology, College of Agriculture, Hawassa University, Ethiopia 2 School of Nutrition, Food Science and Technology, College of Agriculture, Hawassa University, Ethiopia 3 College of Agriculture and Bioresources ...
A. Omer, Demmelash Mulualem, H. Classen, H. Vatanparast, S. Whiting   +4 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Nutritional screening in hospitalized pediatric patients: a systematic review.

Jornal de Pediatria, 2016
OBJECTIVE This systematic review aimed to verify the available scientific evidence on the clinical performance and diagnostic accuracy of nutritional screening tools in hospitalized pediatric patients. DATA SOURCE A search was performed in the Medline (
Adriana Teixeira, K. Viana
semanticscholar   +1 more source