Results 191 to 200 of about 24,001 (238)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Validation of D-SCOPE Questionnaire: Dietitians' Survey of Comfort, Opinions, and Perceptions on Education in Supplements. [PDF]

Nutrients
Harris M, Lindsay K, Bille L, Fioretti N, Hutchins A.   +4 more
europepmc   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

A multimodal mixed-methods approach for holistic insights in Roux-en-Y gastric bypass patients: Protocol for a patient-centered framework. [PDF]

MethodsX
Daboin BEG, Campelo LR, de Brito BB, Pires MCDC, Morais TC, Miguel GPS, Coqueiro JM, Salaroli LB, Lopes AB, Haraguchi FK.   +9 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Successful Anesthetic Management of Patient with Severe Scoliosis Due to Cerebral Palsy Who Underwent Dental Surgery. [PDF]

Int Med Case Rep J
Bani Hani D, Alhowary AA, Gharaibeh S, Al-Zoubi R.   +3 more
europepmc   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Effect of a care-coordinated responsive parenting intervention on obesogenic risk behaviours among mother-infant dyads enrolled in WIC. [PDF]

Pediatr Obes
Ma Y, Bailey-Davis L, Moore AM, Ruggiero CF, McCabe CF, Savage JS.   +5 more
europepmc   +1 more source

Applying Social Cognitive Theory to Understand Perspectives on Child Feeding Practices of Thai Female Caregivers With Young Children With Stunting. [PDF]

Matern Child Nutr
Vinitchagoon T, Rooppat Y, Sukboon P, Limvilai T, Sivaboonyawong N, Somnuek W, Madtohsoh M, Cetthakrikul N, Pongcharoen T.   +8 more
europepmc   +1 more source

Evidence-based nursing practice of radiation-induced oral mucositis in patients with head and neck cancer. [PDF]

Asia Pac J Oncol Nurs
Tian L, Zhang Z, Wu S, Ma J, Tian S, Wang P.   +5 more
europepmc   +1 more source