Results 91 to 100 of about 16,307,918 (298)

O-antigen protects gram-negative bacteria from histone killing. [PDF]

, 2013
Beyond their traditional role of wrapping DNA, histones display antibacterial activity to Gram-negative and -positive bacteria. To identify bacterial components that allow survival to a histone challenge, we selected resistant bacteria from homologous ...
Ryan T Gill, Gill, R., Zychlinsky, A., Eileen Spindler, Arturo Zychlinsky, Arturo Zychlinsky (27502), Catherine Chaput, Eileen Spindler (443500), Catherine Chaput (62317), Spindler, E., Chaput, C., Ryan T. Gill (257311), Chaput Catherine, Zychlinsky Arturo, Spindler Eileen, Gill Ryan T.   +15 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Development and Application of a High-Throughput Method for the Purification and Analysis of Surface Carbohydrates from Klebsiella pneumoniae

Biology
Klebsiella pneumoniae (Kp) is a Gram-negative bacterium, and a leading cause of neonatal sepsis in low- and middle-income countries, often associated with anti-microbial resistance.
Francesca Nonne, Mariagrazia Molfetta, Rebecca Nappini, Chiara La Guidara, Roberta Di Benedetto, Siwaphiwe Mfana, Barbara Bellich, Maria Michelina Raso, Gianmarco Gasperini, Renzo Alfini, Paola Cescutti, Francesco Berlanda Scorza, Neil Ravenscroft, Francesca Micoli, Carlo Giannelli   +14 more
doaj   +1 more source

Convergent synthesis of the tetrasaccharide repeating unit of the O-antigen of Shigella boydii type 9

Beilstein Journal of Organic Chemistry, 2011
A convenient synthesis of the tetrasaccharide repeating unit of the O-antigen of Shigella boydii type 9 has been achieved in excellent yield using a [2 + 2] block glycosylation strategy.
Abhishek Santra, Anup Kumar Misra
doaj   +1 more source

Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen. [PDF]

, 2002
In order to identify T cell epitopes within the Mycobacterium leprae 45-kD serine-rich antigen, we analysed responses to overlapping 17-mer peptides encompassing the whole antigen in non-exposed UK controls, Pakistani leprosy patients and tuberculosis ...
Zafar, S, Dawood, G, Drijfhout, JW, Smith, S, Lopez, FV, Bothamley, G, Brahmbhatt, S, Hussain, R, Dockrell, HM, Ottenhoff, THM   +9 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Validation of electrochemiluminescent (ECL)-based immunoassay to determine the levels of antibodies against Escherichia coli O-lipopolysaccharide antigens

Microbiology Spectrum
Extra-intestinal pathogenic Escherichia coli (ExPEC) is a significant cause of invasive infections, including urinary tract infections, neonatal meningitis, and bacteremia.
Maanan Kamdar, Vichiksha Shah, Sarah Janssen, Elizabeth Garcia Dominguez, Todd Davies, Germie van den Dobbelsteen   +5 more
doaj   +1 more source

Synthesis of the pentasaccharide repeating unit of the O-antigen of E. coli O117:K98:H4

Beilstein Journal of Organic Chemistry, 2014
The pentasaccharide repeating unit of the O-antigen of E. coli O117:K98:H4 strain has been synthesized using a combination of sequential glycosylations and [3 + 2] block synthetic strategy from the suitably protected monosaccharide intermediates ...
Pintu Kumar Mandal
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]

, 1994
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G., Berger, Eric G, Mechtler, Karl, Rusconi, Sandro, Wagner, Ernst, Birnstiel, Max L., Cotten, Matt, Clausen, Erik, Dinter, André, Thurnher, Martin, Berger, Erik G., Clausen, Henrik, Birnstiel, Max L, Wagner E, Cotten M, Clausen H, Mechtler K, Rusconi S, Birnstiel ML, Thurnher M, Berger EG, Dinter A   +21 more
core   +1 more source