Results 101 to 110 of about 11,359,663 (315)

NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infections

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective ...
Liu, Mengya
core  

S. sonnei can resist phagolysosome acidification and promote neutrophil cell death in an O-antigen-dependent manner.

, 2019
A. S. sonnei is collected by neutrophils in large phagosomes. Larvae of the Tg(lyz:dsRed)nz50 strain (labelling neutrophils) were injected in the HBV with WT GFP-S. sonnei. Image taken at 3 hpi. Scale bar = 20 μm. B. S. sonnei is acidified in immune cell
Michael Hollinshead (24820), Thomas B. Clarke (669253), Jayne Watson (8120519), Myrsini Kaforou (475121), Gillian S. Tomlinson (8120531), Gina M. Duggan (8120522), Vanessa Sancho-Shimizu (8120534), Vincenzo Torraca (4173451), Hazel Guerrero-Gutierrez (8120525), Abigail Clements (208088), Rafal J. Mostowy (8120528), Sina Krokowski (5498123), Serge Mostowy (211097)   +12 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Mice Transgenic for the Human Carcinoembryonic Antigen Gene Maintain Its Spatiotemporal Expression Pattern [PDF]

, 1994
The tumor marker carcinoembryonic antigen (CEA) is predominantly expressed in epithelial cells along the gastrointestinal tract and in a variety of adenocarcinomas.
Hirth, Antje, Eades-Perner, Anne-Marie, Neumaier, Michael, Zimmermann, Wolfgang, Putten, Herman van der, Thompson, John A., Kleist, Sabine von   +6 more
core  

Field comparison of circulating antibody assays versus circulating antigen assays for the detection of Schistosomiasis japonica in endemic areas of China [PDF]

, 2014
Schistosomiasis remains a serious public health problem in affected countries, and routine, highly sensitive and cost-effective diagnostic methods are lacking.
Peter Steinmann, Hao Li, Tian, Li-Guang, Li, Hao, Cai, Yu-Chun, Yang Zhou, Jia-Xu Chen, Xu, Jun-Fang, Yan Lu, Li-Guang Tian, Ling-Ling Zhang, Yu-Chun Cai, Yan-Hong Chu, Steinmann, Peter, Chu, Yan-Hong, Chen, Jia-Xu, Chen, Mu-Xin, Lu, Yan, Zhou, Yang, Mu-Xin Chen, Zhang, Ling-Ling, Shao-Hong Chen, Chen, Shao-Hong, Jun-Fang Xu   +23 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

II. Detection of an antigen on resting T cells down-regulated after activation [PDF]

, 1987
The expression of an antigen on porcine T lymphocytes detected by murine monoclonal antibody (mAb) 8/1 was investigated by functional studies and dual-parameter immunofluorescence.
Saalmüller, Armin, Reddehase, Matthias J., Koszinowski, Ulrich H., Jonjic, Stipan, Bühring, Hans-Jörg   +4 more
core   +1 more source

The normal chain length distribution of the O antigen is required for the interaction of Shigella flexneri 2a with polarized Caco-2 cells

Biological Research, 2012
Shigella flexneri causes bacillary dysentery in humans. Essential to the establishment of the disease is the invasion of the colonic epithelial cells. Here we investigated the role of the lipopolysaccharide (LPS) O antigen in the ability of S.
Anilei Hoare, Denisse Bravo, Mara Martinic, Miguel A Valvano, Inés Contreras, Sergio A Álvarez   +5 more
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source